Gene Symbol | DEPDC1 |
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Entrez Gene | 55635 |
Alt Symbol | DEP.8, DEPDC1-V2, DEPDC1A, SDP35 |
Species | Human |
Gene Type | protein-coding |
Description | DEP domain containing 1 |
Other Description | DEP domain-containing protein 1A|cell cycle control protein SDP35 |
Swissprots | Q5TB30 Q9NX21 A8QXE1 Q5TB28 Q05DU3 A8QXE0 Q9NXZ0 Q9H9I3 |
Accessions | CAL40387 CAL40388 CAX21632 CAX21633 EAX06471 EAX06472 EAX06473 EAX06474 EAX06475 EAX06476 EAX06477 Q5TB30 AB281187 BAF91373 AB281274 BAF91374 AJ278112 CAB92444 AK000361 BAA91111 AK000490 BAA91201 AK022792 BAB14246 AK225735 AK299324 BAH13001 AL834208 CAH10663 BC003511 AAH03511 BC011743 BC035506 BC041580 BC065304 AAH65304 BU588593 DB147703 NM_001114120 NP_001107592 NM_017779 NP_060249 |
Function | May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17452976, ECO:0000269|PubMed:20587513}. Note=Colocalizes with ZNF224 at the nucleus. |
Tissue Specificity | Expressed in testis. Up-regulated in bladder cancer cells (at protein level). {ECO:0000269|PubMed:17452976}. |
DEPDC1 CRISPR/Cas9 KO Plasmid (h) - sc-406137 from Santa Cruz Biotechnology
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DEPDC1 HDR Plasmid (h) - sc-406137-HDR from Santa Cruz Biotechnology
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DEPDC1 Double Nickase Plasmid (h) - sc-406137-NIC from Santa Cruz Biotechnology
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DEPDC1 Double Nickase Plasmid (h2) - sc-406137-NIC-2 from Santa Cruz Biotechnology
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DEPDC1 CRISPR Activation Plasmid (h) - sc-406137-ACT from Santa Cruz Biotechnology
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DEPDC1 CRISPR Activation Plasmid (h2) - sc-406137-ACT-2 from Santa Cruz Biotechnology
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DEPDC1 Lentiviral Activation Particles (h) - sc-406137-LAC from Santa Cruz Biotechnology
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DEPDC1 Lentiviral Activation Particles (h2) - sc-406137-LAC-2 from Santa Cruz Biotechnology
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DEPDC1 siRNA (h) - sc-78918 from Santa Cruz Biotechnology
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DEPDC1 shRNA Plasmid (h) - sc-78918-SH from Santa Cruz Biotechnology
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DEPDC1 shRNA (h) Lentiviral Particles - sc-78918-V from Santa Cruz Biotechnology
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DEPDC1A RNAi - H00055635-R01 from Novus Biologicals
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MISSION® esiRNA - EHU128201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7148 from Sigma-Aldrich
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DEPDC1 siRNA (Human) - CRJ0794 from Cohesion Biosciences
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DEPDC1 - MBS8201804 from MyBioSource
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shRNA set against Human DEPDC1(NM_017779.4) - SHH001559 from Creative biogene
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Human DEPDC1 siRNA - orb271295 from Biorbyt
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DEPDC1 shRNA Plasmid (Human) - CHJ0794 from Cohesion Biosciences
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DEPDC1 miRNA 3'UTR clone - MiUTR1H-02777 from Creative biogene
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