| Gene Symbol |
MAEL
|
| Entrez Gene |
84944
|
| Alt Symbol |
CT128, SPATA35
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
maelstrom spermatogenic transposon silencer
|
| Other Description |
cancer/testis antigen 128|maelstrom homolog|protein maelstrom homolog|spermatogenesis associated 35
|
| Swissprots |
Q9UIW6 Q5VZP8 E9JVC3 Q49AP9 B4DY43 Q96JY0
|
| Accessions |
EAW90780 EAW90781 EAW90782 Q96JY0 AK027810 BAB55385 AK131066 AK302253 BAG63605 AL133073 CAB61396 BC028595 AAH28595 BC034310 AAH34310 DQ076156 AAY82463 GU383113 ADU33235 GU383114 ADU33236 HQ447902 ADQ32386 XM_006711582 XP_006711645 XM_006711583 XP_006711646 XM_011510067 XP_011508369 XM_011510068 XP_011508370 NM_001286377 NP_001273306 NM_001286378 NP_001273307 NM_032858 NP_116247
|
| Function |
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP- bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter. {ECO:0000269|PubMed:19693694, ECO:0000269|Ref.1}.
|
![Western Blot: MAEL Overexpression Lysate (Adult Normal) [NBL1-12792] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAEL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6318_MAEL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12792-img0002.jpg)