MAEL

Gene Symbol MAEL
Entrez Gene 84944
Alt Symbol CT128, SPATA35
Species Human
Gene Type protein-coding
Description maelstrom spermatogenic transposon silencer
Other Description cancer/testis antigen 128|maelstrom homolog|protein maelstrom homolog|spermatogenesis associated 35
Swissprots Q9UIW6 Q5VZP8 E9JVC3 Q49AP9 B4DY43 Q96JY0
Accessions EAW90780 EAW90781 EAW90782 Q96JY0 AK027810 BAB55385 AK131066 AK302253 BAG63605 AL133073 CAB61396 BC028595 AAH28595 BC034310 AAH34310 DQ076156 AAY82463 GU383113 ADU33235 GU383114 ADU33236 HQ447902 ADQ32386 XM_006711582 XP_006711645 XM_006711583 XP_006711646 XM_011510067 XP_011508369 XM_011510068 XP_011508370 NM_001286377 NP_001273306 NM_001286378 NP_001273307 NM_032858 NP_116247
Function Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP- bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). {ECO:0000250}.
Tissue Specificity Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter. {ECO:0000269|PubMed:19693694, ECO:0000269|Ref.1}.

Mael CRISPR/Cas9 KO Plasmid (h) - sc-406966 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mael HDR Plasmid (h) - sc-406966-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mael Double Nickase Plasmid (h) - sc-406966-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mael Double Nickase Plasmid (h2) - sc-406966-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mael CRISPR Activation Plasmid (h) - sc-406966-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mael CRISPR Activation Plasmid (h2) - sc-406966-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mael Lentiviral Activation Particles (h) - sc-406966-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mael Lentiviral Activation Particles (h2) - sc-406966-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mael siRNA (h) - sc-75728 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Mael shRNA Plasmid (h) - sc-75728-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Mael shRNA (h) Lentiviral Particles - sc-75728-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU048731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12899 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12899 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MAEL siRNA (Human) - CRJ3714 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MAEL (NM_032858.1) - SHH336591 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MAEL(NM_032858.1) - SHH170093 from Creative biogene

Category siRNA
Species Reactivities Human

MAEL shRNA Plasmid (Human) - CHJ3714 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAEL miRNA 3'UTR clone - MiUTR1H-05999 from Creative biogene

Species Reactivities Human
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