MAEL

Gene Symbol	MAEL
Entrez Gene	84944
Alt Symbol	CT128, SPATA35
Species	Human
Gene Type	protein-coding
Description	maelstrom spermatogenic transposon silencer
Other Description	cancer/testis antigen 128|maelstrom homolog|protein maelstrom homolog|spermatogenesis associated 35
Swissprots	Q9UIW6 Q5VZP8 E9JVC3 Q49AP9 B4DY43 Q96JY0
Accessions	EAW90780 EAW90781 EAW90782 Q96JY0 AK027810 BAB55385 AK131066 AK302253 BAG63605 AL133073 CAB61396 BC028595 AAH28595 BC034310 AAH34310 DQ076156 AAY82463 GU383113 ADU33235 GU383114 ADU33236 HQ447902 ADQ32386 XM_006711582 XP_006711645 XM_006711583 XP_006711646 XM_011510067 XP_011508369 XM_011510068 XP_011508370 NM_001286377 NP_001273306 NM_001286378 NP_001273307 NM_032858 NP_116247
Function	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP- bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). {ECO:0000250}.
Tissue Specificity	Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter. {ECO:0000269|PubMed:19693694, ECO:0000269|Ref.1}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse Mael peptide - ab30463 from Abcam Category Peptide

MAEL Antibody Blocking Peptide - LS-E30892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAEL Blocking Peptide - NBP1-77139PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

MAEL - H00084944-P01 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

MAEL Control Peptide - AP30530CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Maelstrom Peptide - 5667P from ProSci Category Peptide Species Human

MAEL fusion protein - ag10798 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MAEL fusion protein - ag11520 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Protein maelstrom homolog(MAEL) - CSB-YP842695HU CSB-EP842695HU CSB-BP842695HU CSB-MP842695HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAEL-Antibody-C-term-Blocking-Peptide - BP8889b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAEL Peptide, Human - M34GP09069H from Creative Peptides Category Peptide Source Synthetic. Species Human

MAEL fusion protein - Ag24524 from Proteintech Group Category Protein Species Human

Protein maelstrom homolog (MAEL), Recombinant Protein - MBS1371272 from MyBioSource Category Protein Prices $1,210.00, $1,210.00, $1,430.00, $1,430.00, $1,960.00, $1,960.00, $2,425.00, $2,425.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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