MAEL

Gene Symbol MAEL
Entrez Gene 84944
Alt Symbol CT128, SPATA35
Species Human
Gene Type protein-coding
Description maelstrom spermatogenic transposon silencer
Other Description cancer/testis antigen 128|maelstrom homolog|protein maelstrom homolog|spermatogenesis associated 35
Swissprots Q9UIW6 Q5VZP8 E9JVC3 Q49AP9 B4DY43 Q96JY0
Accessions EAW90780 EAW90781 EAW90782 Q96JY0 AK027810 BAB55385 AK131066 AK302253 BAG63605 AL133073 CAB61396 BC028595 AAH28595 BC034310 AAH34310 DQ076156 AAY82463 GU383113 ADU33235 GU383114 ADU33236 HQ447902 ADQ32386 XM_006711582 XP_006711645 XM_006711583 XP_006711646 XM_011510067 XP_011508369 XM_011510068 XP_011508370 NM_001286377 NP_001273306 NM_001286378 NP_001273307 NM_032858 NP_116247
Function Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP- bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). {ECO:0000250}.
Tissue Specificity Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter. {ECO:0000269|PubMed:19693694, ECO:0000269|Ref.1}.

Mael (G-20) - sc-70074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mael (G-20): sc-70074. Western blot analysis of Mael expression in HeLa (A) and Hep G2 (B) whole cell lysates and HeLa nuclear extract (C).

Mael (M-300) - sc-292350 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mael (M-300): sc-292350. Western blot analysis of Mael expression in mouse testis tissue extract.

Mael (Y-16) - sc-70077 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mael (Y-16): sc-70077. Western blot analysis of Mael expression in HeLa whole cell lysate.

Anti-Mael antibody - ab106713 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of Mael in HeLa cells with ab106713 at 20 ug/mL.

Anti-Mael antibody - C-terminal - ab175902 from Abcam

Prices $359.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Mael antibody - C-terminal (ab175902) at 1/1000 dilution + HepG2 cell line lysate at 35 µg

Anti-MAEL Antibody (C-Terminus) - LS-C108687 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry of Maelstrom in HeLa cells with Maelstrom antibody at 5 ug/ml.

MAEL Antibody - NBP1-77139 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MAEL Antibody - NBP1-84359 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: MAEL Antibody [NBP1-84359] Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli & vesicles.

MAEL Antibody - NBP1-84358 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: MAEL Antibody [NBP1-84358] - Staining of human testis shows nuclear positivity in seminiferus duct cells.

Anti-MAEL antibody produced in rabbit - HPA031140 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MAEL: <B>Cat. No. HPA031140</B>: Immunohistochemical staining of human testis shows moderate nuclear positivity in seminiferous duct cells.

Anti-Maelstrom antibody produced in rabbit - SAB3500413 from Sigma-Aldrich

Prices $348.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-Maelstrom: <B>Cat. No. SAB3500413</B>: Western blot analysis of Maelstrom in HeLa cell lysate with Maelstrom antibody at 1 μg/mL.

Anti-MAEL (381-395) antibody produced in rabbit - SAB1103059 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human MAEL was separated on SDS-PAGE, blotted with Anti-MAEL (381-395) (<B>Cat. No. SAB1103059</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500<BR/>2. Antibody dilution 1:500 + MAEL immunizing peptide (human, 381-395)

Anti-MAEL (67-80) antibody produced in rabbit - SAB1103058 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human MAEL was separated on SDS-PAGE, blotted with Anti-MAEL (67-80) (<B>Cat. No. SAB1103058</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000<BR/>2. Antibody dilution 1:1,000 + MAEL immunizing peptide (human, 67-80)

Anti -MAEL (Protein Maelstrom Homolog, CT128, FLJ14904, RP11-102C16.1) - 146624 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

MAEL antibody - AP30530PU-N from Acris Antibodies

Prices $340.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MAEL antibody - H00084944-B01P from Acris Antibodies

Prices $1,530.00
Sizes 500 µg
Host Mouse
Clonality Polyclonal

Maelstrom Antibody - 5667 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Maelstrom in HeLa cell lysate with Maelstrom antibody at 1 μg/mL.

Maelstrom, Polyclonal Antibody - MBS150904 from MyBioSource

Prices $140.00, $355.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Maelstrom Antibody - 254248 from ABBIOTEC

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Maelstrom Antibody - 25082 from Signalway Antibody

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Maelstrom in HeLa cell lysate with Maelstrom antibody at 1 ug/mL.

Anti-MAEL (aa 356-386) polyclonal antibody - DPABH-11780 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MAEL (C-terminal) polyclonal antibody - DPABH-24165 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MAEL (C-terminal) polyclonal antibody - DPAB-L20717 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MAEL polyclonal antibody - DPABT-H11346 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MAEL polyclonal antibody - DPAB-TJ086 from Creative Diagnostics

Host Goat
Clonality Polyclonal
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