Gene Symbol | SLU7 |
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Entrez Gene | 10569 |
Alt Symbol | 9G8, hSlu7 |
Species | Human |
Gene Type | protein-coding |
Description | SLU7 splicing factor homolog (S. cerevisiae) |
Other Description | pre-mRNA-splicing factor SLU7|splicing factor|step II splicing factor SLU7|zinc knuckle motif containing |
Swissprots | Q96FM9 Q3LUJ1 D3DQK2 O95391 Q6RXQ5 Q3LUJ0 |
Accessions | EAW61554 EAW61555 EAW61556 O95391 AF101074 AAD13774 AK000813 AK024875 AK314564 BAG37147 AY486334 AAS59410 BC010634 AAH10634 BE221264 CA976106 DA232975 DA409854 DQ174516 ABA08382 DQ174517 ABA08383 DQ891037 ABM81963 DQ894216 ABM85142 XM_005265793 XP_005265850 XM_011534418 XP_011532720 NM_006425 NP_006416 |
Function | Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15728250}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. |
Top Pathways | Spliceosome |
SLU7 (B-11) - sc-376985 from Santa Cruz Biotechnology
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SLU7 (G-3) - sc-393664 from Santa Cruz Biotechnology
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SLU7 (G-12) - sc-393743 from Santa Cruz Biotechnology
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SLU7 (D-6) - sc-365660 from Santa Cruz Biotechnology
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SLU7 (N-18) - sc-10828 from Santa Cruz Biotechnology
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SLU7 (L-16) - sc-10829 from Santa Cruz Biotechnology
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SLU7 (C-20) - sc-10831 from Santa Cruz Biotechnology
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SLU7 (H-180) - sc-292633 from Santa Cruz Biotechnology
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Anti-SLU7 antibody - ab56710 from Abcam
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Anti-SLU7 antibody - ab137209 from Abcam
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Anti-SLU7 antibody [EPR11111] - ab181138 from Abcam
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Anti-SLU7 / 9G8 Antibody (aa60-86, AP) - LS-C207662 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa60-86, APC) - LS-C207663 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa60-86, Biotin) - LS-C207665 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa60-86, FITC) - LS-C207666 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa60-86, Azide-free, HRP) - LS-C207667 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa60-86, PE) - LS-C207668 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa154-199) - LS-C313956 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa95-144) - LS-C200705 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa59-86) - LS-C325185 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa35-84) - LS-C111380 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa202-251) - LS-C146515 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa113-162) - LS-C120246 from LifeSpan Bioscience
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Anti-SLU7 / 9G8 Antibody (aa60-86) - LS-C159038 from LifeSpan Bioscience
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SLU7 Antibody - NBP2-20403 from Novus Biologicals
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