SLU7
| Gene Symbol | SLU7 |
|---|---|
| Entrez Gene | 10569 |
| Alt Symbol | 9G8, hSlu7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SLU7 splicing factor homolog (S. cerevisiae) |
| Other Description | pre-mRNA-splicing factor SLU7|splicing factor|step II splicing factor SLU7|zinc knuckle motif containing |
| Swissprots | Q96FM9 Q3LUJ1 D3DQK2 O95391 Q6RXQ5 Q3LUJ0 |
| Accessions | EAW61554 EAW61555 EAW61556 O95391 AF101074 AAD13774 AK000813 AK024875 AK314564 BAG37147 AY486334 AAS59410 BC010634 AAH10634 BE221264 CA976106 DA232975 DA409854 DQ174516 ABA08382 DQ174517 ABA08383 DQ891037 ABM81963 DQ894216 ABM85142 XM_005265793 XP_005265850 XM_011534418 XP_011532720 NM_006425 NP_006416 |
| Function | Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15728250}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. |
| Top Pathways | Spliceosome |
SLU7 CRISPR/Cas9 KO Plasmid (h) - sc-409540 from Santa Cruz Biotechnology
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SLU7 HDR Plasmid (h) - sc-409540-HDR from Santa Cruz Biotechnology
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SLU7 Double Nickase Plasmid (h) - sc-409540-NIC from Santa Cruz Biotechnology
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SLU7 Double Nickase Plasmid (h2) - sc-409540-NIC-2 from Santa Cruz Biotechnology
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SLU7 CRISPR Activation Plasmid (h) - sc-409540-ACT from Santa Cruz Biotechnology
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SLU7 CRISPR Activation Plasmid (h2) - sc-409540-ACT-2 from Santa Cruz Biotechnology
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SLU7 Lentiviral Activation Particles (h) - sc-409540-LAC from Santa Cruz Biotechnology
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SLU7 Lentiviral Activation Particles (h2) - sc-409540-LAC-2 from Santa Cruz Biotechnology
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SLU7 siRNA (h) - sc-38372 from Santa Cruz Biotechnology
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SLU7 shRNA Plasmid (h) - sc-38372-SH from Santa Cruz Biotechnology
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SLU7 shRNA (h) Lentiviral Particles - sc-38372-V from Santa Cruz Biotechnology
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SLU7 RNAi - H00010569-R01 from Novus Biologicals
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MISSION® esiRNA - EHU053871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19742 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19742 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10094 from Sigma-Aldrich
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SLU7 siRNA (Human) - CRH7190 from Cohesion Biosciences
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SLU7 - MBS8217025 from MyBioSource
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shRNA set against Human SLU7 (NM_006425.4) - SHH412872 from Creative biogene
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shRNA set against Human SLU7(NM_006425.4) - SHL014698 from Creative biogene
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Human SLU7 siRNA - orb267692 from Biorbyt
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SLU7 shRNA Plasmid (Human) - CHH7190 from Cohesion Biosciences
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SLU7 miRNA 3'UTR clone - MiUTR1H-09632 from Creative biogene
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