| Gene Symbol |
SLU7
|
| Entrez Gene |
10569
|
| Alt Symbol |
9G8, hSlu7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SLU7 splicing factor homolog (S. cerevisiae)
|
| Other Description |
pre-mRNA-splicing factor SLU7|splicing factor|step II splicing factor SLU7|zinc knuckle motif containing
|
| Swissprots |
Q96FM9 Q3LUJ1 D3DQK2 O95391 Q6RXQ5 Q3LUJ0
|
| Accessions |
EAW61554 EAW61555 EAW61556 O95391 AF101074 AAD13774 AK000813 AK024875 AK314564 BAG37147 AY486334 AAS59410 BC010634 AAH10634 BE221264 CA976106 DA232975 DA409854 DQ174516 ABA08382 DQ174517 ABA08383 DQ891037 ABM81963 DQ894216 ABM85142 XM_005265793 XP_005265850 XM_011534418 XP_011532720 NM_006425 NP_006416
|
| Function |
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15728250}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
|
| Top Pathways |
Spliceosome
|
![Western Blot: SLU7 Overexpression Lysate (Adult Normal) [NBL1-16216] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLU7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2696_SLU7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16216-img0002.jpg)