CAV1

Gene Symbol CAV1
Entrez Gene 857
Alt Symbol BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
Species Human
Gene Type protein-coding
Description caveolin 1, caveolae protein, 22kDa
Other Description caveolin-1|cell growth-inhibiting protein 32
Swissprots Q9UQH6 Q9UGP1 Q9UNG1 Q03135
Accessions AAB82538 AAD23745 AAD34722 CAB63654 EAL24360 EAW83503 EAW83504 EAW83505 Q03135 AB209926 BAD93163 AB451284 BAG70098 AB451416 BAG70230 AF070648 AF074993 AF172085 AAQ13608 AI878826 AK290871 BAF83560 AK307501 AL133639 AM393679 CAL38555 AY762103 AAX07830 BC006432 BC009685 AAH09685 BC082246 AAH82246 BG170208 BT007143 AAP35807 DA477166 DA943080 DB266251 DQ890647 ABM81573 DQ893827 ABM84753 EF179102 EF649773 ABW22625 EF649774 ABW22626 EU176473 ABW03274 Z18951 CAA79476 NM_001172895 NP_001166366 NM_001172896 NP_001166367 NM_001172897 NP_001166368 NM_001753 NP_001744
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. {ECO:0000250, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217}.
Subcellular Location Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin- like structure in the membrane. Membrane protein of caveolae.
Tissue Specificity Expressed in muscle and lung, less so in liver, brain and kidney.
Top Pathways Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer

caveolin-1 CRISPR/Cas9 KO Plasmid (h) - sc-400102 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caveolin-1 HDR Plasmid (h) - sc-400102-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caveolin-1 Double Nickase Plasmid (h) - sc-400102-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caveolin-1 Double Nickase Plasmid (h2) - sc-400102-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caveolin-1 CRISPR Activation Plasmid (h) - sc-400102-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caveolin-1 CRISPR Activation Plasmid (h2) - sc-400102-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caveolin-1 Lentiviral Activation Particles (h) - sc-400102-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caveolin-1 Lentiviral Activation Particles (h2) - sc-400102-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caveolin-1 siRNA (h) - sc-29241 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caveolin-1 shRNA Plasmid (h) - sc-29241-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caveolin-1 shRNA (h) Lentiviral Particles - sc-29241-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caveolin-1 siRNA (h2) - sc-44202 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caveolin-1 shRNA Plasmid (h2) - sc-44202-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caveolin-1 shRNA (h2) Lentiviral Particles - sc-44202-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU031251 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg
<B>Immunoblotting</B><BR/>CAV1: <B>Cat. No. EHU031251</B>: Western blot analysis of Caveolin 1 in HeLa cells.<BR/><B>Lanes</B><BR/>1. HeLa cells transfected with Renilla Luciferase esiRNA (RLUC, <B>Cat. No. EHURLUC</B>) as negative control.<BR/>2. HeLa cells transfected with CAV1 esiRNA (<B>Cat. No. EHU031251</B>). Quantitative-Immunoblotting: Lysates were separated on SDS-Page and probed with mouse Monoclonal Anti-Caveolin-1 (1:1000) Clone: CAV1 (<B>Cat. No.SAB4200216</B>) and goat Anti-GAPDH (1:7000) (Acris) antibodies. The signal intensities of indicated bands were quantified using an Odyssey infrared imaging system (Li-COR) and normalized to the GAPDH signal. At 72h post transfection, a 74% CAV1 protein reduction was measured between the negative control RLUC and the sample treated with CAV1 esiRNA.

CompoZr® Knockout ZFN Kit - CKOZFN5402 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5402 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10520 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10520

CAV1 siRNA (Human) - CRH0602 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CAV1 - MBS8212247 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human CAV1 siRNA - orb261104 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CAV1 shRNA Plasmid (Human) - CHH0602 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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