CAV1

Gene Symbol CAV1
Entrez Gene 857
Alt Symbol BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
Species Human
Gene Type protein-coding
Description caveolin 1, caveolae protein, 22kDa
Other Description caveolin-1|cell growth-inhibiting protein 32
Swissprots Q9UQH6 Q9UGP1 Q9UNG1 Q03135
Accessions AAB82538 AAD23745 AAD34722 CAB63654 EAL24360 EAW83503 EAW83504 EAW83505 Q03135 AB209926 BAD93163 AB451284 BAG70098 AB451416 BAG70230 AF070648 AF074993 AF172085 AAQ13608 AI878826 AK290871 BAF83560 AK307501 AL133639 AM393679 CAL38555 AY762103 AAX07830 BC006432 BC009685 AAH09685 BC082246 AAH82246 BG170208 BT007143 AAP35807 DA477166 DA943080 DB266251 DQ890647 ABM81573 DQ893827 ABM84753 EF179102 EF649773 ABW22625 EF649774 ABW22626 EU176473 ABW03274 Z18951 CAA79476 NM_001172895 NP_001166366 NM_001172896 NP_001166367 NM_001172897 NP_001166368 NM_001753 NP_001744
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. {ECO:0000250, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217}.
Subcellular Location Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin- like structure in the membrane. Membrane protein of caveolae.
Tissue Specificity Expressed in muscle and lung, less so in liver, brain and kidney.
Top Pathways Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer

Caveolin-1 (D46G3) XP ® Rabbit mAb (HRP Conjugate) - 12506 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D46G3
Western blot analysis of extracts from HeLa and NIH/3T3 cells using Caveolin-1 (D46G3) XP ® Rabbit mAb (HRP Conjugate).

Phospho-Caveolin-1 (Tyr14) Antibody - 3251 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated (-) or H 2 O 2 -treated (+), using Phospho-Caveolin-1 (Tyr14) Antibody (upper) and Caveolin-1 (D46G3) XP ® Rabbit mAb #3267 (lower).

Caveolin-1 (D46G3) XP ® Rabbit mAb - 3267 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D46G3
Western blot analysis of extracts from various cell types using Caveolin-1 (D46G3) XP ® Rabbit mAb.

Caveolin-1 Antibody - 3238 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Caveolin-1 Antibody.

caveolin-1 (N-20) - sc-894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caveolin-1 (N-20): sc-894. Western blot analysis of caveolin-1 p22 expression in A-431 (A), NIH/3T3 (B), MDA-MB-231 (C) and SK-LMS-1 (D) whole cell lysates.

caveolin-1 (H-97) - sc-7875 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caveolin-1 (H-97): sc-7875. Western blot analysis of human recombinant caveolin-1 fusion protein.

caveolin-1 (7C8) - sc-53564 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caveolin-1 (7C8): sc-53564. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

caveolin-1 (C20B) - sc-135860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
caveolin-1 (C20B): sc-135860. Western blot analysis of caveolin-1 expression in SL-29 whole cell lysate.

caveolin-1 (4H312) - sc-70516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caveolin-1 (4H312): sc-70516. Western blot analysis of caveolin-1 expression in CHO whole cell lysate.

p-caveolin-1 (B-9) - sc-373837 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of caveolin-1 phosphorylation in untreated (A,D), pervanadate treated (B,E) and pervanadate and lambda protein phosphatase (sc-200312A) treated (C,F) ECV304 whole cell lysates. Antibodies tested include p-caveolin-1 (B-9): sc-373837 (A,B,C) and caveolin-1 (N-20): sc-894 (D,E,F).

p-caveolin-1 (G-10) - sc-373836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of caveolin-1 phosphorylation in untreated (A,D), pervanadate treated (B,E) and pervanadate and lambda protein phosphatase (sc-200312A) treated (C,F) ECV304 whole cell lysates. Antibodies tested include p-caveolin-1 (G-10): sc-373836 (A,B,C) and caveolin-1 (N-20): sc-894 (D,E,F).

p-caveolin-1 (Tyr 14) - sc-14037 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of caveolin-1 phosphorylation in untreated (A,D), pervanadate treated (B,E) and pervanadate and lambda protein phosphatase treated (C,F) A-431 whole cell lysates. Antibodies tested include p-caveolin-1 (Tyr 14)-R: sc-14037-R (A,B,C) and caveolin-1 (N-20): sc-894 (D,E,F).

p-caveolin-1 (Tyr 14) - sc-101653 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-caveolin-1 (Tyr 14): sc-101653. Western blot analysis of phosphorylated caveolin-1 expression in untreated (A) and H<sub>2</sub>O<sub>2</sub>-treated (B) NIH/3T3 whole cell lysates.

Anti-Caveolin 1/3 antibody - ab93952 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caveolin 1/3 antibody (ab93952) at 1/2000 dilutionLane 1 : Jurkat cell lysate at 36 µgLane 2 : Adult rat ventricular myocyte lysate at 50 µg

Anti-Caveolin 1 antibody - Cytoplasmic domain - ab76325 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Caveolin-1 (phospho Y14) antibody - ab131235 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caveolin-1 (phospho Y14) antibody (ab131235) at 1/500 dilutionLane 1 : Lysate of untreated 3T3 cells Lane 2 : Lysate of H2O2 treated 3T3 cells

Anti-Caveolin-1 (phospho Y14) antibody - ab194869 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caveolin-1 (phospho Y14) antibody (ab194869) at 1/500 dilutionLane 1 : Untreated 3T3 cell extractLane 2 : Hydrogen peroxide treated 3T3 cell extract

Anti-Caveolin-1 (phospho Y14) antibody - ab195920 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caveolin-1 (phospho Y14) antibody (ab195920) at 1/500 dilutionLane 1 : H2O2 treated NIH-3T3 whole cell lysates with antigen-specific peptideLane 2 : H2O2 treated NIH-3T3 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-Caveolin-1 (phospho Y14) antibody [EPR2288Y] - ab75876 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2288Y
All lanes : Anti-Caveolin-1 (phospho Y14) antibody [EPR2288Y] (ab75876) at 1/2000 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysate treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/1000 dilution

Anti-Caveolin-1 antibody - ab81397 from Abcam

Host Sheep
Clonality Polyclonal
Immunofluorescence analysis of mouse superior cervical ganglion cells, staining Caveolin-1 with ab81397.Cells were fixed with paraformaldehye, permeablized 0.5% Triton X-100 and blocked with normal chicken serum for 30 min at room temperature. Samples were incubated overnight with primary antibody (1/100 followed by incubation for 1 hour with an AlexaFluor®488-conjugated anti-rabbit secondary antibody (1/500).

Anti-Caveolin-1 antibody - ab39541 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Caveolin-1 antibody - ab52230 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caveolin-1 antibody (ab52230) at 1/500 dilutionLane 1 : HuvEc cell extracts, untreated.Lane 2 : HuvEc cell extracts, treated with the immunising peptide.

Anti-Caveolin-1 antibody - ab86711 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caveolin-1 antibody (ab86711) at 1/2000 dilutionLane 1 : A431 cells, unstimulatedLane 2 : A431 cells, stimulated with pervanadate (1 mM for 30 min)Observed band size : 21 kDa (why is the actual band size different from the predicted?)

Anti-Caveolin-1 antibody - ab64481 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab64481, at 1/100 dilution, staining Caveolin-1 in human lung tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-Caveolin-1 antibody [7C8] - ab17052 from Abcam

Prices $398.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 7C8
ab17052 at a 1/500 dilution staining hamster CHO cells by ICC/IF. The cells were paraformaldehyde fixed and blocked with 10% serum prior to incubation with the antibody. Bound antibody was detected using a FITC conjugated goat anti-mouse antibody.See Abreview
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