CILP

Gene Symbol	CILP
Entrez Gene	8483
Alt Symbol	CILP-1, HsT18872
Species	Human
Gene Type	protein-coding
Description	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Other Description	cartilage intermediate layer protein 1|cartilage intermediate layer protein 1 C1|cartilage intermediate layer protein 1 C2|cartilage intermediate-layer protein
Swissprots	Q8IYI5 O75339 B2R8F7 Q6UW99
Accessions	AAF14689 BAA76692 EAW77717 O75339 AF035408 AAC33838 AK225652 AK225926 AK313352 BAG36154 AL602624 AY358904 AAQ89263 BC035776 AAH35776 CA503413 DB071945 DQ891272 ABM82198 DQ894460 ABM85386 NM_003613 NP_003604
Function	Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. {ECO:0000269|PubMed:12746903, ECO:0000269|PubMed:15864306}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15864306}.
Tissue Specificity	Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses. {ECO:0000269|PubMed:12483726, ECO:0000269|PubMed:15864306, ECO:0000269|PubMed:9722583, ECO:0000269|PubMed:9722584}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CILP (K-20) - sc-47839 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CILP (H-199) - sc-134540 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CILP (N-17) - sc-47841 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CILP antibody - ab51955 from Abcam Prices $370.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-CILP antibody [EPR16303] - ab192881 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR16303

Anti-CILP Antibody (aa724-1184) - LS-C77776 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-CILP Antibody (aa22-720, Biotin) - LS-C125368 from LifeSpan Bioscience Prices $650.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-CILP Antibody (aa604-864, Biotin) - LS-C298789 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CILP Antibody (aa603-846, Biotin) - LS-C299007 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CILP Antibody (aa604-864, FITC) - LS-C302958 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CILP Antibody (aa955-1004) - LS-C151790 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CILP Antibody (aa603-846, FITC) - LS-C304868 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CILP Antibody (aa603-846) - LS-C293186 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CILP Antibody (clone 2C5) - LS-C198573 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2C5

Anti-CILP Antibody (aa604-864) - LS-C293188 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CILP Antibody (Internal) - LS-C54656 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

CILP-1 Antibody [Unconjugated] - AF5504 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

CILP-1 Antibody - C-Terminal Fragment - AF4477 from Novus Biologicals Prices $99.00, $329.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

CILP-1 Antibody - NB100-41106 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Goat Clonality Polyclonal

CILP-1 Antibody - NBP1-81667 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CILP-1 Antibody (2C5) - H00008483-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2C5

CILP-1 Antibody - H00008483-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

CILP-1 Antibody [Biotin] - BAF4477 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Sheep Clonality Polyclonal

CILP-1 Antibody [Biotin] - BAF5504 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Goat Clonality Polyclonal

CILP-1 Antibody (2D10) - H00008483-M03 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2D10

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