CILP

Gene Symbol CILP
Entrez Gene 8483
Alt Symbol CILP-1, HsT18872
Species Human
Gene Type protein-coding
Description cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Other Description cartilage intermediate layer protein 1|cartilage intermediate layer protein 1 C1|cartilage intermediate layer protein 1 C2|cartilage intermediate-layer protein
Swissprots Q8IYI5 O75339 B2R8F7 Q6UW99
Accessions AAF14689 BAA76692 EAW77717 O75339 AF035408 AAC33838 AK225652 AK225926 AK313352 BAG36154 AL602624 AY358904 AAQ89263 BC035776 AAH35776 CA503413 DB071945 DQ891272 ABM82198 DQ894460 ABM85386 NM_003613 NP_003604
Function Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. {ECO:0000269|PubMed:12746903, ECO:0000269|PubMed:15864306}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15864306}.
Tissue Specificity Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses. {ECO:0000269|PubMed:12483726, ECO:0000269|PubMed:15864306, ECO:0000269|PubMed:9722583, ECO:0000269|PubMed:9722584}.

Cartilage intermediate layer protein 1 (CILP), Human, ELISA Kit - CSB-EL005437HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cartilage intermediate layer protein 1 (CILP), Human, ELISA Kit - E01C1728 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Cartilage intermediate layer protein 1, CILP, Human, ELISA Kit - E1182h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Cartilage intermediate layer protein 1, ELISA Kit - MBS283539 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7217197 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7220284 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7237184 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7221570 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7200072 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7209801 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7216474 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7214432 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7201127 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7210930 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7236322 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cartilage intermediate layer protein 1 (CILP), ELISA Kit - MBS7213805 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cartilage intermediate layer protein, nucleotide pyrophosphohydrolase, ELISA Kit - MBS909350 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human CILP is typically less than 23.4 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 93.75 pg/ml-6000 pg/ml.

Human Cartilage intermediate layer protein 1(CILP) ELISA kit - CSB-EL005437HU from Cusabio

Category ELISA Kit
Sensitivity 23.4 pg/ml
Range 93.75 pg/ml-6000 pg/ml

Human CILP ELISA Kit (Custom ELISA) - LS-F16334 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Mouse CILP ELISA Kit (Custom ELISA) - LS-F16332 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Pig CILP ELISA Kit (Custom ELISA) - LS-F16333 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Custom Human CILP-1 ELISA - ELH-CILP1 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human CILP-1 Elisa kit - orb305225 from Biorbyt

Category ELISA Kit
Prices $1,148.00, $1,981.00, $4,284.00
Sizes 96 assays, 192 assays, 480 assays

Human CILP-1 ELISA - RAB1370 from Sigma-Aldrich

Prices $615.00
Sizes 1 kt

Human CILP-1 ELISA - ELH-CILP1-1 from RayBiotech

Category ELISA Kit
Prices $471.00, $847.80, $1,884.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit
Search more