CILP

Gene Symbol CILP
Entrez Gene 8483
Alt Symbol CILP-1, HsT18872
Species Human
Gene Type protein-coding
Description cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Other Description cartilage intermediate layer protein 1|cartilage intermediate layer protein 1 C1|cartilage intermediate layer protein 1 C2|cartilage intermediate-layer protein
Swissprots Q8IYI5 O75339 B2R8F7 Q6UW99
Accessions AAF14689 BAA76692 EAW77717 O75339 AF035408 AAC33838 AK225652 AK225926 AK313352 BAG36154 AL602624 AY358904 AAQ89263 BC035776 AAH35776 CA503413 DB071945 DQ891272 ABM82198 DQ894460 ABM85386 NM_003613 NP_003604
Function Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. {ECO:0000269|PubMed:12746903, ECO:0000269|PubMed:15864306}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15864306}.
Tissue Specificity Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses. {ECO:0000269|PubMed:12483726, ECO:0000269|PubMed:15864306, ECO:0000269|PubMed:9722583, ECO:0000269|PubMed:9722584}.

CILP CRISPR/Cas9 KO Plasmid (h) - sc-411179 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CILP HDR Plasmid (h) - sc-411179-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CILP Double Nickase Plasmid (h) - sc-411179-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CILP Double Nickase Plasmid (h2) - sc-411179-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CILP CRISPR Activation Plasmid (h) - sc-411179-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CILP CRISPR Activation Plasmid (h2) - sc-411179-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CILP Lentiviral Activation Particles (h) - sc-411179-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CILP Lentiviral Activation Particles (h2) - sc-411179-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CILP siRNA (h) - sc-60384 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CILP shRNA Plasmid (h) - sc-60384-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CILP shRNA (h) Lentiviral Particles - sc-60384-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CILP-1 RNAi - H00008483-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU052841 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2164 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2164 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CILP siRNA (Human) - CRH5562 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CILP - MBS8228930 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CILP (NM_003613.3) - SHH264097 from Creative biogene

Category siRNA
Species Reactivities Human

Human CILP siRNA - orb266064 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CILP shRNA Plasmid (Human) - CHH5562 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CILP miRNA 3'UTR clone - MiUTR3H-06019 from Creative biogene

Species Reactivities Human
Search more