CILP

Gene Symbol	CILP
Entrez Gene	8483
Alt Symbol	CILP-1, HsT18872
Species	Human
Gene Type	protein-coding
Description	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Other Description	cartilage intermediate layer protein 1|cartilage intermediate layer protein 1 C1|cartilage intermediate layer protein 1 C2|cartilage intermediate-layer protein
Swissprots	Q8IYI5 O75339 B2R8F7 Q6UW99
Accessions	AAF14689 BAA76692 EAW77717 O75339 AF035408 AAC33838 AK225652 AK225926 AK313352 BAG36154 AL602624 AY358904 AAQ89263 BC035776 AAH35776 CA503413 DB071945 DQ891272 ABM82198 DQ894460 ABM85386 NM_003613 NP_003604
Function	Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. {ECO:0000269|PubMed:12746903, ECO:0000269|PubMed:15864306}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15864306}.
Tissue Specificity	Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses. {ECO:0000269|PubMed:12483726, ECO:0000269|PubMed:15864306, ECO:0000269|PubMed:9722583, ECO:0000269|PubMed:9722584}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CILP protein fragment - ab160049 from Abcam Category Protein Source Wheat germ Species Human

Human CILP protein fragment - ab182802 from Abcam Category Protein Source E. coli Species Human

CILP Antibody Blocking Peptide - LS-E23582 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CILP Antibody Blocking Peptide - LS-E26140 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CILP-1 Protein - H00008483-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CILP blocking peptide - GTX89301-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human CILP-1, CF - 5504-CP-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Met1-Arg720, with a C-terminal 6-His tag

Goat anti CILP antibody Immunizing peptide - orb16844 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human CILP Protein - abx065736 from Abbexa Category Protein Source E.coli Species Human

CILP Peptide - AC21-0970-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CILP1 - H00008483-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CILP1 - H00008483-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cartilage Intermediate Layer Protein (CILP), Human - 20-8459 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

CILP Peptide - 45-402P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Rat

CILP fusion protein - ag8089 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CILP fusion protein - Ag4894 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human CILP, His-tagged - CILP-538H from Creative Biomart Category Protein Source NSO Cells Species Human

Recombinant Cartilage Intermediate Layer Protein (CILP) - RPC382Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cartilage Intermediate Layer Protein (CILP) - RPC382Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cartilage Intermediate Layer Protein (CILP) - RPC382Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Cartilage intermediate layer protein 1(CILP) - CSB-YP005437HU CSB-EP005437HU CSB-BP005437HU CSB-MP005437HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human CILP-1 Protein, CF - 5504-CP from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Met1-Arg720, with a C-terminal 6-His tag Species Human

Cartilage Intermediate Layer Protein (CILP), Recombinant Protein - MBS2009475 from MyBioSource Category Protein Prices $175.00, $370.00, $575.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Cartilage intermediate layer protein 1 (CILP), Recombinant Protein - MBS1087099 from MyBioSource Category Protein Prices $1,240.00, $1,240.00, $1,460.00, $1,460.00, $1,985.00, $1,985.00, $2,445.00, $2,445.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CILP, Peptide - MBS425228 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

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