| Gene Symbol |
APPL2
|
| Entrez Gene |
55198
|
| Alt Symbol |
DIP13B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
|
| Other Description |
DCC-interacting protein 13-beta|DIP13 beta|adapter protein containing PH domain, PTB domain and leucine zipper motif 2
|
| Swissprots |
F5GZG0 F8W1P5 Q8NEU8 Q9NVL2 B7Z4B0 B7Z411 Q8N4R7
|
| Accessions |
EAW97762 EAW97763 EAW97764 Q8NEU8 AK001521 BAG50931 AK290562 BAF83251 AK293783 BAH11594 AK296610 BAH12397 AK297100 BAH12496 AK310377 AY113704 AAM55530 BC028008 BC033731 AAH33731 DN993818 DQ892107 ABM83033 DQ895301 ABM86227 XM_006719472 XP_006719535 XM_011538530 XP_011536832 XM_011538531 XP_011536833 XM_011538532 XP_011536834 NM_001251904 NP_001238833 NM_001251905 NP_001238834 NM_018171 NP_060641
|
| Function |
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction. {ECO:0000269|PubMed:15016378}.
|
| Subcellular Location |
Early endosome membrane {ECO:0000269|PubMed:15016378}; Peripheral membrane protein {ECO:0000269|PubMed:15016378}. Nucleus {ECO:0000269|PubMed:15016378}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
|
| Tissue Specificity |
High levels in brain, heart, kidney and skeletal muscle. {ECO:0000269|PubMed:11431708}.
|