Gene Symbol | APPL2 |
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Entrez Gene | 55198 |
Alt Symbol | DIP13B |
Species | Human |
Gene Type | protein-coding |
Description | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 |
Other Description | DCC-interacting protein 13-beta|DIP13 beta|adapter protein containing PH domain, PTB domain and leucine zipper motif 2 |
Swissprots | F5GZG0 F8W1P5 Q8NEU8 Q9NVL2 B7Z4B0 B7Z411 Q8N4R7 |
Accessions | EAW97762 EAW97763 EAW97764 Q8NEU8 AK001521 BAG50931 AK290562 BAF83251 AK293783 BAH11594 AK296610 BAH12397 AK297100 BAH12496 AK310377 AY113704 AAM55530 BC028008 BC033731 AAH33731 DN993818 DQ892107 ABM83033 DQ895301 ABM86227 XM_006719472 XP_006719535 XM_011538530 XP_011536832 XM_011538531 XP_011536833 XM_011538532 XP_011536834 NM_001251904 NP_001238833 NM_001251905 NP_001238834 NM_018171 NP_060641 |
Function | Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction. {ECO:0000269|PubMed:15016378}. |
Subcellular Location | Early endosome membrane {ECO:0000269|PubMed:15016378}; Peripheral membrane protein {ECO:0000269|PubMed:15016378}. Nucleus {ECO:0000269|PubMed:15016378}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. |
Tissue Specificity | High levels in brain, heart, kidney and skeletal muscle. {ECO:0000269|PubMed:11431708}. |
APPL2 CRISPR/Cas9 KO Plasmid (h) - sc-402991 from Santa Cruz Biotechnology
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APPL2 HDR Plasmid (h) - sc-402991-HDR from Santa Cruz Biotechnology
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APPL2 Double Nickase Plasmid (h) - sc-402991-NIC from Santa Cruz Biotechnology
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APPL2 Double Nickase Plasmid (h2) - sc-402991-NIC-2 from Santa Cruz Biotechnology
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APPL2 CRISPR Activation Plasmid (h) - sc-402991-ACT from Santa Cruz Biotechnology
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APPL2 CRISPR Activation Plasmid (h2) - sc-402991-ACT-2 from Santa Cruz Biotechnology
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APPL2 Lentiviral Activation Particles (h) - sc-402991-LAC from Santa Cruz Biotechnology
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APPL2 Lentiviral Activation Particles (h2) - sc-402991-LAC-2 from Santa Cruz Biotechnology
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APPL2 siRNA (h) - sc-61982 from Santa Cruz Biotechnology
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APPL2 shRNA Plasmid (h) - sc-61982-SH from Santa Cruz Biotechnology
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APPL2 shRNA (h) Lentiviral Particles - sc-61982-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU066351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3361 from Sigma-Aldrich
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APPL2 siRNA (Human) - CRJ0549 from Cohesion Biosciences
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APPL2 - MBS8226216 from MyBioSource
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shRNA set against Human APPL2 (NM_018171.3) - SHH238762 from Creative biogene
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shRNA set against Human APPL2(NM_018171.3) - SHG066717 from Creative biogene
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Human APPL2 siRNA - orb271050 from Biorbyt
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APPL2 shRNA Plasmid (Human) - CHJ0549 from Cohesion Biosciences
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APPL2 miRNA 3'UTR clone - MiUTR1H-00493 from Creative biogene
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