| Gene Symbol |
CNOT6
|
| Entrez Gene |
57472
|
| Alt Symbol |
CCR4, Ccr4a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CCR4-NOT transcription complex, subunit 6
|
| Other Description |
CCR4-NOT transcription complex subunit 6|carbon catabolite repression 4 protein|carbon catabolite repressor protein 4 homolog|cytoplasmic deadenylase
|
| Swissprots |
D3DWR0 A7MD46 Q9ULM6
|
| Accessions |
CAD32417 EAW53752 EAW53753 EAW53754 Q9ULM6 AB033020 BAA86508 AI025725 AK023599 AK314752 BAG37291 AL110144 BC015331 BC027476 AAH27476 BC073142 BC090918 BC114958 BC152469 AAI52470 BC160174 AAI60174 BF940524 BM769589 BQ232180 D20789 DA370007 XM_005265953 XP_005266010 XM_011534605 XP_011532907 XM_011534606 XP_011532908 XM_011534607 XP_011532909 XM_011534608 XP_011532910 XM_011534609 XP_011532911 NM_001303241 NP_001290170 NM_015455
|
| Function |
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:11889047, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:21233283}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
|
| Top Pathways |
RNA degradation
|