CNOT6

Gene Symbol	CNOT6
Entrez Gene	57472
Alt Symbol	CCR4, Ccr4a
Species	Human
Gene Type	protein-coding
Description	CCR4-NOT transcription complex, subunit 6
Other Description	CCR4-NOT transcription complex subunit 6|carbon catabolite repression 4 protein|carbon catabolite repressor protein 4 homolog|cytoplasmic deadenylase
Swissprots	D3DWR0 A7MD46 Q9ULM6
Accessions	CAD32417 EAW53752 EAW53753 EAW53754 Q9ULM6 AB033020 BAA86508 AI025725 AK023599 AK314752 BAG37291 AL110144 BC015331 BC027476 AAH27476 BC073142 BC090918 BC114958 BC152469 AAI52470 BC160174 AAI60174 BF940524 BM769589 BQ232180 D20789 DA370007 XM_005265953 XP_005266010 XM_011534605 XP_011532907 XM_011534606 XP_011532908 XM_011534607 XP_011532909 XM_011534608 XP_011532910 XM_011534609 XP_011532911 NM_001303241 NP_001290170 NM_015455
Function	Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:11889047, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:21233283}.
Subcellular Location	Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CNOT6 full length protein - ab163559 from Abcam Category Protein Source Wheat germ Species Human

Human CNOT6 protein fragment - ab163560 from Abcam Category Protein Source Wheat germ Species Human

CNOT6 Antibody Blocking Peptide - LS-E6150 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNOT6 Antibody Blocking Peptide - LS-E14959 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CNOT6 Protein - H00057472-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human CNOT6 Protein - H00057472-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CNOT6-Antibody-C-term-Blocking-Peptide - BP18775b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CNOT6 Blocking Peptide - 33R-2486 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CNOT6 - H00057472-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CNOT6 - H00057472-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CNOT6 - H00057472-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CNOT6 fusion protein - ag11506 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CNOT6 fusion protein - ag11399 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CCR4-NOT transcription complex subunit 6(CNOT6) - CSB-YP892149HU CSB-EP892149HU CSB-BP892149HU CSB-MP892149HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CCR4-NOT transcription complex subunit 6 (CNOT6), Recombinant Protein - MBS1478134 from MyBioSource Category Protein Prices $1,355.00, $1,355.00, $1,570.00, $1,570.00, $2,245.00, $2,245.00, $2,710.00, $2,710.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CNOT6 Recombinant Protein Antigen - NBP1-86564PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CNOT6 Peptide, Human - M34GP03382H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more