CNOT6
| Gene Symbol | CNOT6 |
|---|---|
| Entrez Gene | 57472 |
| Alt Symbol | CCR4, Ccr4a |
| Species | Human |
| Gene Type | protein-coding |
| Description | CCR4-NOT transcription complex, subunit 6 |
| Other Description | CCR4-NOT transcription complex subunit 6|carbon catabolite repression 4 protein|carbon catabolite repressor protein 4 homolog|cytoplasmic deadenylase |
| Swissprots | D3DWR0 A7MD46 Q9ULM6 |
| Accessions | CAD32417 EAW53752 EAW53753 EAW53754 Q9ULM6 AB033020 BAA86508 AI025725 AK023599 AK314752 BAG37291 AL110144 BC015331 BC027476 AAH27476 BC073142 BC090918 BC114958 BC152469 AAI52470 BC160174 AAI60174 BF940524 BM769589 BQ232180 D20789 DA370007 XM_005265953 XP_005266010 XM_011534605 XP_011532907 XM_011534606 XP_011532908 XM_011534607 XP_011532909 XM_011534608 XP_011532910 XM_011534609 XP_011532911 NM_001303241 NP_001290170 NM_015455 |
| Function | Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:11889047, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:21233283}. |
| Subcellular Location | Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. |
| Top Pathways | RNA degradation |
CNOT6 CRISPR/Cas9 KO Plasmid (h) - sc-406273 from Santa Cruz Biotechnology
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CNOT6 HDR Plasmid (h) - sc-406273-HDR from Santa Cruz Biotechnology
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CNOT6 Double Nickase Plasmid (h) - sc-406273-NIC from Santa Cruz Biotechnology
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CNOT6 Double Nickase Plasmid (h2) - sc-406273-NIC-2 from Santa Cruz Biotechnology
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CNOT6 CRISPR Activation Plasmid (h) - sc-406273-ACT from Santa Cruz Biotechnology
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CNOT6 CRISPR Activation Plasmid (h2) - sc-406273-ACT-2 from Santa Cruz Biotechnology
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CNOT6 Lentiviral Activation Particles (h) - sc-406273-LAC from Santa Cruz Biotechnology
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CNOT6 Lentiviral Activation Particles (h2) - sc-406273-LAC-2 from Santa Cruz Biotechnology
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CNOT6 siRNA (h) - sc-72944 from Santa Cruz Biotechnology
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CNOT6 shRNA Plasmid (h) - sc-72944-SH from Santa Cruz Biotechnology
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CNOT6 shRNA (h) Lentiviral Particles - sc-72944-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU017571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6323 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6323 from Sigma-Aldrich
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CNOT6 siRNA (Human) - CRJ1465 from Cohesion Biosciences
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CNOT6 RNAi - H00057472-R01 from Novus Biologicals
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CNOT6 - MBS827977 from MyBioSource
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shRNA set against Human CNOT6 (NM_015455.3) - SHH266461 from Creative biogene
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shRNA set against Human CNOT6(NM_015455.3) - SHG187593 from Creative biogene
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CNOT6 shRNA Plasmid (Human) - CHJ1465 from Cohesion Biosciences
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CNOT6 miRNA 3'UTR clone - MiUTR1H-02279 from Creative biogene
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