MACROD1

Gene Symbol MACROD1
Entrez Gene 28992
Alt Symbol LRP16
Species Human
Gene Type protein-coding
Description MACRO domain containing 1
Other Description MACRO domain-containing protein 1|O-acetyl-ADP-ribose deacetylase MACROD1|[Protein ADP-ribosylglutamate] hydrolase
Swissprots Q9UH96 Q9BQ69
Accessions EAW74192 EAW74193 Q9BQ69 AF086206 AF202922 AAF15294 BC000270 AAH00270 BC003188 AAH03188 BC007297 AAH07297 BC008316 AAH08316 BQ637198 HG503847 XM_005273939 XP_005273996 XM_005273940 XP_005273997 XM_006718521 XP_006718584 XM_006718522 XP_006718585 XM_011544970 XP_011543272 XM_011544971 XP_011543273 XM_011544972 XP_011543274 NM_014067 NP_054786
Function Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. {ECO:0000269|PubMed:17893710, ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:2347
Subcellular Location Nucleus {ECO:0000269|PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.

LRP16 (Q-14) - sc-243327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRP16 (Q-14): sc-243327. Western blot analysis of LRP16 expression in HeLa (A), Jurkat (B) and NIH/3T3 (C) whole cell lysates.

LRP16 (A-14) - sc-243328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRP16 (A-14): sc-243328. Western blot analysis of LRP16 expression in Jurkat whole cell lysate.

Anti-MACROD1 antibody - ab122688 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of Human cell line A-431 shows positivity in mitochondria. Recommended concentration of ab122688 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-MACROD1 antibody - N-terminal - ab157603 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MACROD1 antibody - N-terminal (ab157603) at 1 µg/ml + Human fetal brain lysate at 10 µg

Anti-MACROD1 / LRP16 Antibody (aa83-132) - LS-C170516 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

MACROD1 Antibody - NBP1-93535 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: MACROD1 Antibody [NBP1-93535] - Staining of human cell line A-431 shows positivity in mitochondria.

Anti-MACROD1 antibody produced in rabbit - HPA041031 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MACROD1: <B>Cat. No. HPA041031</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity with granular pattern in glandular cells.

MACROD1 Antibody - N-terminal region (ARP68610_P050) - ARP68610_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MACROD1 antibody - orb185399 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

Anti-MACROD1 (aa 83-132) polyclonal antibody - DPABH-05918 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MACROD1 polyclonal antibody - DPABH-20995 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MACROD1 monoclonal antibody - DCABH-200908 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

MACROD1 Antibody,FITC conjugated - CSB-PA860244LC01HU from Cusabio

Host Rabbit
Clonality Polyclonal

MACROD1 Antibody,Biotin conjugated - CSB-PA860244LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal

MACROD1 Antibody - CSB-PA860244LA01HU from Cusabio

Host Rabbit
Clonality Polyclonal

MACROD1 Antibody,HRP conjugated - CSB-PA860244LB01HU from Cusabio

Host Rabbit
Clonality Polyclonal

Anti-MACROD1 / LRP16 Antibody (Biotin) - LS-C379242 from LifeSpan Bioscience

Prices $285.00, $385.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MACROD1 / LRP16 Antibody (FITC) - LS-C379244 from LifeSpan Bioscience

Prices $285.00, $385.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MACROD1 / LRP16 Antibody - LS-C379238 from LifeSpan Bioscience

Prices $285.00, $385.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MACROD1 / LRP16 Antibody (HRP) - LS-C379239 from LifeSpan Bioscience

Prices $285.00, $385.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

MACROD1 / LRP16 antibody - TA331983 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Host: Rabbit; Target Name: MACROD1; Sample Tissue: Fetal Brain lysates; Antibody Dilution: 1.0ug/ml

Anti-MACROD1 / LRP16 Antibody (aa83-132, Biotin) - LS-C475951 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MACROD1 / LRP16 Antibody (aa83-132, HRP) - LS-C475953 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MACROD1 / LRP16 Antibody (aa83-132, FITC) - LS-C475952 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MACROD1 antibody (FITC) - orb189713 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
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