| Gene Symbol | MACROD1 |
|---|---|
| Entrez Gene | 28992 |
| Alt Symbol | LRP16 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MACRO domain containing 1 |
| Other Description | MACRO domain-containing protein 1|O-acetyl-ADP-ribose deacetylase MACROD1|[Protein ADP-ribosylglutamate] hydrolase |
| Swissprots | Q9UH96 Q9BQ69 |
| Accessions | EAW74192 EAW74193 Q9BQ69 AF086206 AF202922 AAF15294 BC000270 AAH00270 BC003188 AAH03188 BC007297 AAH07297 BC008316 AAH08316 BQ637198 HG503847 XM_005273939 XP_005273996 XM_005273940 XP_005273997 XM_006718521 XP_006718584 XM_006718522 XP_006718585 XM_011544970 XP_011543272 XM_011544971 XP_011543273 XM_011544972 XP_011543274 NM_014067 NP_054786 |
| Function | Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. {ECO:0000269|PubMed:17893710, ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:2347 |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. |
LRP16 CRISPR/Cas9 KO Plasmid (h) - sc-405616 from Santa Cruz Biotechnology
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LRP16 HDR Plasmid (h) - sc-405616-HDR from Santa Cruz Biotechnology
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LRP16 Double Nickase Plasmid (h) - sc-405616-NIC from Santa Cruz Biotechnology
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LRP16 Double Nickase Plasmid (h2) - sc-405616-NIC-2 from Santa Cruz Biotechnology
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LRP16 CRISPR Activation Plasmid (h) - sc-405616-ACT from Santa Cruz Biotechnology
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LRP16 CRISPR Activation Plasmid (h2) - sc-405616-ACT-2 from Santa Cruz Biotechnology
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LRP16 Lentiviral Activation Particles (h) - sc-405616-LAC from Santa Cruz Biotechnology
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LRP16 Lentiviral Activation Particles (h2) - sc-405616-LAC-2 from Santa Cruz Biotechnology
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LRP16 siRNA (h) - sc-96535 from Santa Cruz Biotechnology
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LRP16 shRNA Plasmid (h) - sc-96535-SH from Santa Cruz Biotechnology
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LRP16 shRNA (h) Lentiviral Particles - sc-96535-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU121551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12890 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12890 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00374 from Sigma-Aldrich
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MACROD1 siRNA (Human) - CRH9155 from Cohesion Biosciences
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LRP16 CRISPR/Cas9 KO Plasmid (h2) - sc-405616-KO-2 from Santa Cruz Biotechnology
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LRP16 HDR Plasmid (h2) - sc-405616-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MACROD1 (NM_014067.3) - SHH336463 from Creative biogene
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MACROD1 shRNA Plasmid (Human) - CHH9155 from Cohesion Biosciences
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MACROD1 miRNA 3'UTR clone - MiUTR3H-11212 from Creative biogene
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