| Gene Symbol |
MACROD1
|
| Entrez Gene |
28992
|
| Alt Symbol |
LRP16
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MACRO domain containing 1
|
| Other Description |
MACRO domain-containing protein 1|O-acetyl-ADP-ribose deacetylase MACROD1|[Protein ADP-ribosylglutamate] hydrolase
|
| Swissprots |
Q9UH96 Q9BQ69
|
| Accessions |
EAW74192 EAW74193 Q9BQ69 AF086206 AF202922 AAF15294 BC000270 AAH00270 BC003188 AAH03188 BC007297 AAH07297 BC008316 AAH08316 BQ637198 HG503847 XM_005273939 XP_005273996 XM_005273940 XP_005273997 XM_006718521 XP_006718584 XM_006718522 XP_006718585 XM_011544970 XP_011543272 XM_011544971 XP_011543273 XM_011544972 XP_011543274 NM_014067 NP_054786
|
| Function |
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. {ECO:0000269|PubMed:17893710, ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:2347
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
|