MACROD1

Gene Symbol MACROD1
Entrez Gene 28992
Alt Symbol LRP16
Species Human
Gene Type protein-coding
Description MACRO domain containing 1
Other Description MACRO domain-containing protein 1|O-acetyl-ADP-ribose deacetylase MACROD1|[Protein ADP-ribosylglutamate] hydrolase
Swissprots Q9UH96 Q9BQ69
Accessions EAW74192 EAW74193 Q9BQ69 AF086206 AF202922 AAF15294 BC000270 AAH00270 BC003188 AAH03188 BC007297 AAH07297 BC008316 AAH08316 BQ637198 HG503847 XM_005273939 XP_005273996 XM_005273940 XP_005273997 XM_006718521 XP_006718584 XM_006718522 XP_006718585 XM_011544970 XP_011543272 XM_011544971 XP_011543273 XM_011544972 XP_011543274 NM_014067 NP_054786
Function Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. {ECO:0000269|PubMed:17893710, ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:2347
Subcellular Location Nucleus {ECO:0000269|PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.

MACROD1 / LRP16 Antibody Blocking Peptide - LS-E24604 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human MACROD1 - MACROD1-993H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1(MACROD1) - CSB-YP860244HU CSB-EP860244HU CSB-BP860244HU CSB-MP860244HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

MACROD1 Recombinant Protein Antigen - NBP1-93535PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

MACROD1 Peptide, Human - M34GP09060H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

O-acetyl-ADP-ribose deacetylase MACROD1 (MACROD1), Recombinant Protein - MBS1417739 from MyBioSource

Category Protein
Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,705.00, $1,705.00, $2,170.00, $2,170.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

MACROD1 Recombinant Protein Antigen - NBP2-58835PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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