Gene Symbol | SPPL2C |
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Entrez Gene | 162540 |
Alt Symbol | IMP5 |
Species | Human |
Gene Type | protein-coding |
Description | signal peptide peptidase like 2C |
Other Description | IMP-5|SPP-like 2C|intramembrane protease 5|signal peptide peptidase-like 2C |
Swissprots | Q8WVZ6 Q8TC67 Q8IUH8 |
Accessions | AAO12541 EAW93564 Q8IUH8 BC022041 AAH22041 BC025401 AAH25401 NM_175882 NP_787078 |
Function | Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305|PubMed:16829952}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000269|PubMed:16829952}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15385547}. |
IMP5 CRISPR/Cas9 KO Plasmid (h) - sc-414843 from Santa Cruz Biotechnology
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IMP5 HDR Plasmid (h) - sc-414843-HDR from Santa Cruz Biotechnology
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IMP5 Double Nickase Plasmid (h) - sc-414843-NIC from Santa Cruz Biotechnology
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IMP5 Double Nickase Plasmid (h2) - sc-414843-NIC-2 from Santa Cruz Biotechnology
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IMP5 CRISPR Activation Plasmid (h) - sc-414843-ACT from Santa Cruz Biotechnology
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IMP5 CRISPR Activation Plasmid (h2) - sc-414843-ACT-2 from Santa Cruz Biotechnology
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IMP5 Lentiviral Activation Particles (h) - sc-414843-LAC from Santa Cruz Biotechnology
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IMP5 Lentiviral Activation Particles (h2) - sc-414843-LAC-2 from Santa Cruz Biotechnology
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IMP5 siRNA (h) - sc-93786 from Santa Cruz Biotechnology
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IMP5 shRNA Plasmid (h) - sc-93786-SH from Santa Cruz Biotechnology
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IMP5 shRNA (h) Lentiviral Particles - sc-93786-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10656 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10656 from Sigma-Aldrich
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SPPL2C siRNA (Human) - CRJ5955 from Cohesion Biosciences
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SPPL2C - MBS8225113 from MyBioSource
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shRNA set against Human IMP5 (NM_175882.2) - SHH319293 from Creative biogene
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SPPL2C shRNA Plasmid (Human) - CHJ5955 from Cohesion Biosciences
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SPPL2C miRNA 3'UTR clone - MiUTR3H-09884 from Creative biogene
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