| Gene Symbol |
AMOTL2
|
| Entrez Gene |
51421
|
| Alt Symbol |
LCCP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
angiomotin like 2
|
| Other Description |
Leman coiled-coil protein|angiomotin-like protein 2
|
| Swissprots |
Q96F99 Q53EP1 E9PHW3 Q9Y2J4 A8K6F1 Q9UKB4 B7Z5Q1
|
| Accessions |
EAW79150 EAW79151 EAW79152 Q9Y2J4 AA056579 AB023206 BAA76833 AF175966 AAD56361 AI214560 AK001343 AK074731 BAG51994 AK091040 BAG52268 AK223598 BAD97318 AK291616 BAF84305 AK299270 BAH12987 AW294642 BC011454 AAH11454 BC025981 AAH25981 BU178516 DA330301 XM_006713654 XP_006713717 XM_011512877 XP_011511179 XM_011512878 XP_011511180 XM_011512879 XP_011511181 XM_011512880 XP_011511182 XM_011512881 XP_011511183 NM_001278683 NP_001265612 NM_001278685 NP_001265614 NM_016201 NP_057285
|
| Function |
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. {ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771}.
|
| Subcellular Location |
Recycling endosome {ECO:0000250}.
|