AMOTL2

Gene Symbol	AMOTL2
Entrez Gene	51421
Alt Symbol	LCCP
Species	Human
Gene Type	protein-coding
Description	angiomotin like 2
Other Description	Leman coiled-coil protein|angiomotin-like protein 2
Swissprots	Q96F99 Q53EP1 E9PHW3 Q9Y2J4 A8K6F1 Q9UKB4 B7Z5Q1
Accessions	EAW79150 EAW79151 EAW79152 Q9Y2J4 AA056579 AB023206 BAA76833 AF175966 AAD56361 AI214560 AK001343 AK074731 BAG51994 AK091040 BAG52268 AK223598 BAD97318 AK291616 BAF84305 AK299270 BAH12987 AW294642 BC011454 AAH11454 BC025981 AAH25981 BU178516 DA330301 XM_006713654 XP_006713717 XM_011512877 XP_011511179 XM_011512878 XP_011511180 XM_011512879 XP_011511181 XM_011512880 XP_011511182 XM_011512881 XP_011511183 NM_001278683 NP_001265612 NM_001278685 NP_001265614 NM_016201 NP_057285
Function	Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. {ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771}.
Subcellular Location	Recycling endosome {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AMOTL2 protein (His-DHFR tag) - ab127618 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

Human AMOTL2 protein fragment - ab132654 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

AMOTL2 Antibody Blocking Peptide - LS-E9820 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AMOTL2 Protein - H00051421-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AMOTL2-Antibody-Center-Blocking-Peptide - BP8860c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AMOTL2 Blocking Peptide - 33R-8968 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Angiomotin-like protein 2 - H00051421-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Angiomotin-like protein 2 - H00051421-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AMOTL2 fusion protein - ag19953 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

AMOTL2 fusion protein - ag19971 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Angiomotin-like protein 2 / AMOTL2 - TP319781 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

AMOTL2 Peptide, Human - M34GP00564H from Creative Peptides Category Peptide Source Synthetic. Species Human

AMOTL2 Recombinant Protein Antigen - NBP2-57184PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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