| Gene Symbol |
FOXL2
|
| Entrez Gene |
668
|
| Alt Symbol |
BPES, BPES1, PFRK, PINTO, POF3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
forkhead box L2
|
| Other Description |
forkhead box protein L2|forkhead transcription factor FOXL2
|
| Swissprots |
P58012 Q4ZGJ3
|
| Accessions |
AAQ01519 AAY21821 AAY21822 AAY21823 P58012 AF301906 AAK01352 AI089172 BC019896 AAH19896 BC062549 AAH62549 BF512713 DQ089670 AAY89234 DQ089671 AAY89235 DQ089672 AAY89236 FJ598614 NM_023067 NP_075555
|
| Function |
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:19744555}.
|
| Tissue Specificity |
In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
|