| Gene Symbol | FOXL2 |
|---|---|
| Entrez Gene | 668 |
| Alt Symbol | BPES, BPES1, PFRK, PINTO, POF3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | forkhead box L2 |
| Other Description | forkhead box protein L2|forkhead transcription factor FOXL2 |
| Swissprots | P58012 Q4ZGJ3 |
| Accessions | AAQ01519 AAY21821 AAY21822 AAY21823 P58012 AF301906 AAK01352 AI089172 BC019896 AAH19896 BC062549 AAH62549 BF512713 DQ089670 AAY89234 DQ089671 AAY89235 DQ089672 AAY89236 FJ598614 NM_023067 NP_075555 |
| Function | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:19744555}. |
| Tissue Specificity | In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary. |
FOXL2 CRISPR/Cas9 KO Plasmid (h) - sc-403351 from Santa Cruz Biotechnology
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FOXL2 HDR Plasmid (h) - sc-403351-HDR from Santa Cruz Biotechnology
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FOXL2 Double Nickase Plasmid (h) - sc-403351-NIC from Santa Cruz Biotechnology
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FOXL2 Double Nickase Plasmid (h2) - sc-403351-NIC-2 from Santa Cruz Biotechnology
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FOXL2 CRISPR Activation Plasmid (h) - sc-403351-ACT from Santa Cruz Biotechnology
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FOXL2 CRISPR Activation Plasmid (h2) - sc-403351-ACT-2 from Santa Cruz Biotechnology
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FOXL2 Lentiviral Activation Particles (h) - sc-403351-LAC from Santa Cruz Biotechnology
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FOXL2 Lentiviral Activation Particles (h2) - sc-403351-LAC-2 from Santa Cruz Biotechnology
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FOXL2 siRNA (h) - sc-106837 from Santa Cruz Biotechnology
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FOXL2 shRNA Plasmid (h) - sc-106837-SH from Santa Cruz Biotechnology
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FOXL2 shRNA (h) Lentiviral Particles - sc-106837-V from Santa Cruz Biotechnology
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FOXL2 RNAi - H00000668-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN8906 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8906 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09165 from Sigma-Aldrich
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FOXL2 siRNA (Human) - CRH0463 from Cohesion Biosciences
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FOXL2 - MBS8208297 from MyBioSource
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FOXL2 HDR Plasmid (h2) - sc-403351-HDR-2 from Santa Cruz Biotechnology
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FOXL2 CRISPR/Cas9 KO Plasmid (h2) - sc-403351-KO-2 from Santa Cruz Biotechnology
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shRNA set against Human FOXL2 (NM_023067.3) - SHH296685 from Creative biogene
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Human FOXL2 siRNA - orb260965 from Biorbyt
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FOXL2 shRNA Plasmid (Human) - CHH0463 from Cohesion Biosciences
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