TLR7

Gene Symbol TLR7
Entrez Gene 51284
Alt Symbol TLR7-like
Species Human
Gene Type protein-coding
Description toll-like receptor 7
Other Description toll-like receptor 7-like
Swissprots D1CS69 Q9NR98 Q9NYK1
Accessions AAZ99021 AAZ99022 AAZ99023 AAZ99024 AAZ99025 AAZ99026 EAW98807 Q9NYK1 AB445659 BAG55056 AF240467 AAF60188 AF245702 AAF78035 AK313858 BAG36586 AY358292 AAQ88659 BC033651 AAH33651 DQ891269 ABM82195 DQ894457 ABM85383 NM_016562 NP_057646
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.
Tissue Specificity Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Top Pathways Toll-like receptor signaling pathway, Measles, Influenza A

TLR7 CRISPR/Cas9 KO Plasmid (h) - sc-401189 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR7 HDR Plasmid (h) - sc-401189-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR7 Double Nickase Plasmid (h) - sc-401189-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR7 Double Nickase Plasmid (h2) - sc-401189-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR7 CRISPR Activation Plasmid (h) - sc-401189-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR7 CRISPR Activation Plasmid (h2) - sc-401189-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR7 Lentiviral Activation Particles (h) - sc-401189-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR7 Lentiviral Activation Particles (h2) - sc-401189-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR7 siRNA (h) - sc-40266 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLR7 shRNA Plasmid (h) - sc-40266-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLR7 shRNA (h) Lentiviral Particles - sc-40266-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLR7 RNAi - H00051284-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU011031 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21404 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21404 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10330 from Sigma-Aldrich

Category miRNA

TLR7 siRNA (Human) - CRH9662 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TLR7 - MBS8221557 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TLR7 (NM_016562.3) - SHH428020 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TLR7(NM_016562.3) - SHL073206 from Creative biogene

Category siRNA
Species Reactivities Human

Human TLR7 siRNA - orb270164 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TLR7 shRNA Plasmid (Human) - CHH9662 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TLR7 miRNA 3'UTR clone - MiUTR1H-10438 from Creative biogene

Species Reactivities Human
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