TLR7

Gene Symbol TLR7
Entrez Gene 51284
Alt Symbol TLR7-like
Species Human
Gene Type protein-coding
Description toll-like receptor 7
Other Description toll-like receptor 7-like
Swissprots D1CS69 Q9NR98 Q9NYK1
Accessions AAZ99021 AAZ99022 AAZ99023 AAZ99024 AAZ99025 AAZ99026 EAW98807 Q9NYK1 AB445659 BAG55056 AF240467 AAF60188 AF245702 AAF78035 AK313858 BAG36586 AY358292 AAQ88659 BC033651 AAH33651 DQ891269 ABM82195 DQ894457 ABM85383 NM_016562 NP_057646
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.
Tissue Specificity Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Top Pathways Toll-like receptor signaling pathway, Measles, Influenza A

Toll-like Receptor 7 Antibody - 2633 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with human TLR7, and from Ramos and A20 cell lines using Toll-like Receptor 7 Antibody.

Toll-like Receptor 7 (D7) Rabbit mAb - 5632 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7
Western blot analysis of extracts from various cell lines using Toll-like Receptor 7 (D7) Rabbit mAb.

TLR7 (H-114) - sc-30004 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TLR7 (N-20) - sc-13207 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR7 (H-20) - sc-13208 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR7 (V-20) - sc-16245 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLR7 (V-20): sc-16245. Immunoperoxidase staining of formalin fixed, paraffin-embedded human premenopausal uterus tissue showing cytoplasmic staining of glandular cells.

TLR7 (4F4) - sc-57463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
TLR7 (4F4): sc-57463. Western blot analysis of TLR7 expression in Ramos whole cell lysate.

Anti-TLR7 antibody - ab24184 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TLR7 antibody (ab24184) at 0.5 µg/mlLane 2 : Anti-TLR7 antibody (ab24184) at 1 µg/mlLane 3 : Anti-TLR7 antibody (ab24184) at 2 µg/mlLane 1 : Daudi cell lysates.Lane 2 : Daudi cell lysates.Lane 3 : Daudi cell lysates.

Anti-TLR7 antibody - ab104527 from Abcam

Host Goat
Clonality Polyclonal

Anti-TLR7 antibody - ab89509 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-TLR7 antibody (ab89509) at 5 µg/ml + Daoy cell lysate at 50 µg

Anti-TLR7 antibody - ab13730 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TLR7 antibody - ab13732 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Intracellular staining by FACS analysis of TLR7 in Ramos cells (A) using ab13732 at 1µg/ml.  Histogram B shows the rabbit isotype control.

Anti-TLR7 antibody [4F4] - ab28048 from Abcam

Prices $382.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F4
Anti-TLR7 antibody [4F4] (ab28048) at 1/1000 dilution + 80 µg Ramos cell lysateSecondarygoat anti mouse secondary antibody conjugated to HRP developed using the ECL technique

Anti-TLR7 antibody [EPR2088(2)] - ab124928 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2088(2)
All lanes : Anti-TLR7 antibody [EPR2088(2)] (ab124928) at 20 µg (unpurified)Lane 1 : Ramos cell lysateLane 2 : Daudi cell lysateLysates/proteins at 20 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG at 1/1000 dilution

Anti-TLR7 antibody (FITC) - ab72329 from Abcam

Host Rabbit
Clonality Polyclonal
ab72329 at 2µg/106cells staining TLR7 in human PBMC by flow cytometry (red). Shaded histogram represents FITC-conjugated rabbit IgG isotype control.

Anti-TLR7 antibody [IMG4G6] - ab107605 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone IMG4G6
Anti-TLR7 antibody [IMG4G6] (ab107605) at 10 µg/ml + Ramos cell lysate at 40 µg

Anti-TLR7 antibody [IMG4G6] - BSA and Azide free - ab175806 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone IMG4G6

Anti-TLR7 antibody (Phycoerythrin) - ab72331 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab72331 at 5µg/106 cells staining TLR7 in human PBMCs by flow cytometry (shown in red). Shaded histogram represents PE-conjugated rabbit IgG isotype control.

Anti-TLR7 Antibody (aa900-950) IHC-plus™ - LS-B4828 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TLR7 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4828 concentration 10 ug/ml.

Anti-TLR7 Antibody (aa465-483) IHC-plus™ - LS-B4827 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TLR7 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4827 concentration 10 ug/ml.

Anti-TLR7 Antibody (Internal) - LS-C10758 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TLR7 Antibody - LS-C10767 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TLR7 Antibody (C-Terminus) - LS-C10764 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-TLR7 Antibody (C-Terminus) - LS-C76428 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TLR7 Antibody - LS-C48515 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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