ESX1

Gene Symbol ESX1
Entrez Gene 80712
Alt Symbol ESX1L, ESXR1
Species Human
Gene Type protein-coding
Description ESX homeobox 1
Other Description ESX1-related protein|extraembryonic, spermatogenesis, homeobox 1 homolog|homeobox protein ESX1
Swissprots B0QYU3 Q7Z6K7 Q8N693
Accessions ABS01452 ABS01453 ABS01454 ABS01455 ABS01456 ABS01457 ABS01458 ABS01459 ABS01460 ABS01461 ABS01462 ABS01463 ABS01464 ABS01465 ABS01466 ABS01467 ABS01468 ABS01469 ABS01470 ABS01471 ABS01472 ABS01473 ABS01474 ABS01475 ABS01476 ABS01477 ABS01478 ABS01479 ABS01480 ABS01481 ABS01482 ABS01483 EAX02755 Q8N693 AK097704 AY114148 AAM62141 BC042633 AAH42633 BC053599 AAH53599 NM_153448 NP_703149
Function May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. {ECO:0000269|PubMed:15235584, ECO:0000269|PubMed:15897875}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15235584}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Tissue Specificity Expressed in placenta and testis. Expressed in testicular germ cell tumors. {ECO:0000269|PubMed:11374906, ECO:0000269|PubMed:15235584}.
Top Pathways Signaling pathways regulating pluripotency of stem cells

ESX1 (B-9) - sc-365740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ESX1 (B-9): sc-365740. Western blot analysis of ESX1 expression in non-transfected: sc-117752 (A) and human ESX1 transfected: sc-116502 (B) 293T whole cell lysates.

ESX1 (H-184) - sc-98689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ESX1 (H-184): sc-98689. Western blot analysis of ESX1 expression in non-transfected: sc-117752 (A) and human ESX1 transfected: sc-116502 (B) 293T whole cell lysates.

ESX1 (C-17) - sc-79478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ESX1 (C-17): sc-79478. Western blot analysis of ESX1 expression in HeLa (A) and HEK293 (B) whole cell lysates and human liver tissue extract (C).

ESX1 (Q-19) - sc-79481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ESX1 antibody - ab106614 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of ESX1 in Human testis tissue with ab106614 at 20 ug/mL.

Anti-ESX1 antibody - ab49109 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ESX1 antibody (ab49109) at 1.25 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-ESX1 Antibody (Internal) IHC-plus™ - LS-B4630 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ESX1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4630 concentration 5 ug/ml.

Anti-ESX1 Antibody (aa28-55, APC) - LS-C235083 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ESX1 Antibody (aa28-55, AP) - LS-C235084 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ESX1 Antibody (aa28-55, Biotin) - LS-C235085 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ESX1 Antibody (N-Terminus) - LS-C30751 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Testis Lysate

Anti-ESX1 Antibody (aa35-84) - LS-C30965 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-ESX1 Antibody (aa28-55, FITC) - LS-C235086 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ESX1 Antibody (aa28-55, PE) - LS-C235087 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ESX1 Antibody (aa28-55, Azide-free, HRP) - LS-C249939 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ESX1 Antibody (aa27-55) - LS-C321205 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ESX1 Antibody (aa28-55) - LS-C159573 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ESX1 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The ESX1 antibody detected the ESX1 protein (arrow).

ESX1 Antibody - NBP1-77114 from Novus Biologicals

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ESX1 Antibody [NBP1-77114] - Immunofluorescence of ESX1 in human testis tissue with ESX1 antibody at 20 ug/mL.

ESX1 Antibody - NBP2-13973 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ESX1 Antibody - NBP1-71994 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

ESX1 Antibody - H00080712-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

Anti-ESX1 antibody produced in rabbit - SAB2900808 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ESX1 (C-Terminus), antibody produced in rabbit: <B>Cat. No. SAB2900808</B>: Anti-ESX1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 μg/mL.

Anti-ESX1 antibody produced in rabbit - HPA051992 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ESX1:<B>Cat. No. HPA051992</B>: Immunohistochemical staining of human uterus, post-menopause, shows moderate nuclear positivity in stroma and glandular cells.

Anti-ESX1 (AB1) antibody produced in rabbit - AV36220 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV36220</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1.25 μg/mL in cell type HepG2

Anti-ESX1 antibody produced in rabbit - SAB3500396 from Sigma-Aldrich

Prices $348.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ESX1: <B>Cat. No. SAB3500396</B>: Western blot analysis of ESX1 in human testis tissue lysate with ESX1 antibody at (A) 1 and (B) 2 μg/mL.
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