ESX1

Gene Symbol ESX1
Entrez Gene 80712
Alt Symbol ESX1L, ESXR1
Species Human
Gene Type protein-coding
Description ESX homeobox 1
Other Description ESX1-related protein|extraembryonic, spermatogenesis, homeobox 1 homolog|homeobox protein ESX1
Swissprots B0QYU3 Q7Z6K7 Q8N693
Accessions ABS01452 ABS01453 ABS01454 ABS01455 ABS01456 ABS01457 ABS01458 ABS01459 ABS01460 ABS01461 ABS01462 ABS01463 ABS01464 ABS01465 ABS01466 ABS01467 ABS01468 ABS01469 ABS01470 ABS01471 ABS01472 ABS01473 ABS01474 ABS01475 ABS01476 ABS01477 ABS01478 ABS01479 ABS01480 ABS01481 ABS01482 ABS01483 EAX02755 Q8N693 AK097704 AY114148 AAM62141 BC042633 AAH42633 BC053599 AAH53599 NM_153448 NP_703149
Function May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. {ECO:0000269|PubMed:15235584, ECO:0000269|PubMed:15897875}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15235584}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Tissue Specificity Expressed in placenta and testis. Expressed in testicular germ cell tumors. {ECO:0000269|PubMed:11374906, ECO:0000269|PubMed:15235584}.
Top Pathways Signaling pathways regulating pluripotency of stem cells

ESX1 CRISPR/Cas9 KO Plasmid (h) - sc-410160 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESX1 HDR Plasmid (h) - sc-410160-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESX1 Double Nickase Plasmid (h) - sc-410160-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESX1 Double Nickase Plasmid (h2) - sc-410160-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESX1 CRISPR Activation Plasmid (h) - sc-410160-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESX1 CRISPR Activation Plasmid (h2) - sc-410160-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESX1 Lentiviral Activation Particles (h) - sc-410160-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESX1 Lentiviral Activation Particles (h2) - sc-410160-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ESX1 siRNA (h) - sc-77289 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ESX1 shRNA Plasmid (h) - sc-77289-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ESX1 shRNA (h) Lentiviral Particles - sc-77289-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN7995 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7995 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00576 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00576

ESX1 siRNA (Human) - CRJ2883 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ESX1 RNAi - H00080712-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ESX1 - MBS8233077 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ESX1 (NM_153448.3) - SHH287485 from Creative biogene

Category siRNA
Species Reactivities Human

ESX1 shRNA Plasmid (Human) - CHJ2883 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ESX1 miRNA 3'UTR clone - MiUTR4H-TG03174 from Creative biogene

Species Reactivities Human
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