ESX1

Gene Symbol	ESX1
Entrez Gene	80712
Alt Symbol	ESX1L, ESXR1
Species	Human
Gene Type	protein-coding
Description	ESX homeobox 1
Other Description	ESX1-related protein|extraembryonic, spermatogenesis, homeobox 1 homolog|homeobox protein ESX1
Swissprots	B0QYU3 Q7Z6K7 Q8N693
Accessions	ABS01452 ABS01453 ABS01454 ABS01455 ABS01456 ABS01457 ABS01458 ABS01459 ABS01460 ABS01461 ABS01462 ABS01463 ABS01464 ABS01465 ABS01466 ABS01467 ABS01468 ABS01469 ABS01470 ABS01471 ABS01472 ABS01473 ABS01474 ABS01475 ABS01476 ABS01477 ABS01478 ABS01479 ABS01480 ABS01481 ABS01482 ABS01483 EAX02755 Q8N693 AK097704 AY114148 AAM62141 BC042633 AAH42633 BC053599 AAH53599 NM_153448 NP_703149
Function	May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. {ECO:0000269|PubMed:15235584, ECO:0000269|PubMed:15897875}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15235584}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Tissue Specificity	Expressed in placenta and testis. Expressed in testicular germ cell tumors. {ECO:0000269|PubMed:11374906, ECO:0000269|PubMed:15235584}.
Top Pathways	Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ESX1 protein fragment - ab164279 from Abcam Category Protein Source Wheat germ Species Human

ESX1 Antibody Blocking Peptide - LS-E4880 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ESX1 Antibody Blocking Peptide - LS-E30860 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ESX1 Antibody Blocking Peptide - LS-E12960 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ESX1 Antibody Blocking Peptide - LS-E13209 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ESX1 Protein - H00080712-Q01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

ESX1 Blocking Peptide - NBP1-77114PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

ESX1-Antibody-N-term-Blocking-Peptide - BP17259a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ESX1 Peptide - GTX85009-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

ESX1 Blocking Peptide - 33R-5960 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ESX1 - H00080712-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ESX1 - H00080712-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ESX1 Control Peptide - AP30320CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ESX1 Peptide - 5597P from ProSci Category Peptide Species Human

ESX1 fusion protein - Ag6269 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ESX1, His-tagged - ESX1-12563H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Homeobox protein ESX1(ESX1) - CSB-YP847642HU CSB-EP847642HU CSB-BP847642HU CSB-MP847642HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ESX1 Recombinant Protein Antigen - NBP2-13973PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ESX1 Peptide, Human - M34GP05089H from Creative Peptides Category Peptide Source Synthetic. Species Human

Homeobox protein ESX1 (ESX1), Recombinant Protein - MBS1289254 from MyBioSource Category Protein Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,895.00, $1,895.00, $2,360.00, $2,360.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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