| Gene Symbol |
ESX1
|
| Entrez Gene |
80712
|
| Alt Symbol |
ESX1L, ESXR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ESX homeobox 1
|
| Other Description |
ESX1-related protein|extraembryonic, spermatogenesis, homeobox 1 homolog|homeobox protein ESX1
|
| Swissprots |
B0QYU3 Q7Z6K7 Q8N693
|
| Accessions |
ABS01452 ABS01453 ABS01454 ABS01455 ABS01456 ABS01457 ABS01458 ABS01459 ABS01460 ABS01461 ABS01462 ABS01463 ABS01464 ABS01465 ABS01466 ABS01467 ABS01468 ABS01469 ABS01470 ABS01471 ABS01472 ABS01473 ABS01474 ABS01475 ABS01476 ABS01477 ABS01478 ABS01479 ABS01480 ABS01481 ABS01482 ABS01483 EAX02755 Q8N693 AK097704 AY114148 AAM62141 BC042633 AAH42633 BC053599 AAH53599 NM_153448 NP_703149
|
| Function |
May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. {ECO:0000269|PubMed:15235584, ECO:0000269|PubMed:15897875}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15235584}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
|
| Tissue Specificity |
Expressed in placenta and testis. Expressed in testicular germ cell tumors. {ECO:0000269|PubMed:11374906, ECO:0000269|PubMed:15235584}.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|