ESX1

Gene Symbol ESX1
Entrez Gene 80712
Alt Symbol ESX1L, ESXR1
Species Human
Gene Type protein-coding
Description ESX homeobox 1
Other Description ESX1-related protein|extraembryonic, spermatogenesis, homeobox 1 homolog|homeobox protein ESX1
Swissprots B0QYU3 Q7Z6K7 Q8N693
Accessions ABS01452 ABS01453 ABS01454 ABS01455 ABS01456 ABS01457 ABS01458 ABS01459 ABS01460 ABS01461 ABS01462 ABS01463 ABS01464 ABS01465 ABS01466 ABS01467 ABS01468 ABS01469 ABS01470 ABS01471 ABS01472 ABS01473 ABS01474 ABS01475 ABS01476 ABS01477 ABS01478 ABS01479 ABS01480 ABS01481 ABS01482 ABS01483 EAX02755 Q8N693 AK097704 AY114148 AAM62141 BC042633 AAH42633 BC053599 AAH53599 NM_153448 NP_703149
Function May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. {ECO:0000269|PubMed:15235584, ECO:0000269|PubMed:15897875}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15235584}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Tissue Specificity Expressed in placenta and testis. Expressed in testicular germ cell tumors. {ECO:0000269|PubMed:11374906, ECO:0000269|PubMed:15235584}.
Top Pathways Signaling pathways regulating pluripotency of stem cells

ESX1 (h): 293T Lysate - sc-112165 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

ESX1 (h2): 293T Lysate - sc-116502 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Panoply™ Human ESX1 Knockdown Stable Cell Line - CSC-DC005089 from Creative biogene

Category Cell Line
Species Human
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