TXK

Gene Symbol	TXK
Entrez Gene	7294
Alt Symbol	BTKL, PSCTK5, PTK4, RLK, TKL
Species	Human
Gene Type	protein-coding
Description	TXK tyrosine kinase
Other Description	PTK4 protein tyrosine kinase 4|protein-tyrosine kinase 4|resting lymphocyte kinase|tyrosine kinase|tyrosine-protein kinase TXK
Swissprots	Q14220 P42681
Accessions	AAA19597 AAA19598 AAA19599 AAA19600 AAB60412 EAW93051 EAW93052 EAW93053 P42681 AK300141 BAG61927 AK307055 BC017829 BC166632 AAI66632 DB103575 L27071 AAA74557 XM_011513746 XP_011512048 XM_011513747 XP_011512049 XM_011513748 XP_011512050 XR_925166 NM_003328 NP_003319
Function	Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17177976}. Nucleus {ECO:0000269|PubMed:17177976}. Cell membrane {ECO:0000269|PubMed:17177976}; Peripheral membrane protein {ECO:0000269|PubMed:17177976}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
Tissue Specificity	Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:7951233}.
Top Pathways	Leukocyte transendothelial migration

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Txk (H-85) - sc-50339 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Txk (C-20) - sc-1105 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Txk (M-20) - sc-1106 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TXK antibody - ab57673 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TXK antibody - ab57674 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TXK antibody - Aminoterminal end - ab37818 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (N-Terminus, AP) - LS-C283559 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (N-Terminus, APC) - LS-C283560 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (N-Terminus, FITC) - LS-C283562 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (N-Terminus, Azide-free, HRP) - LS-C283564 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (N-Terminus, Biotin) - LS-C283563 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (N-Terminus, PE) - LS-C283565 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (aa286-509, Biotin) - LS-C301066 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (aa286-509, FITC) - LS-C303238 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (N-Terminus) - LS-C330687 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (aa286-509) - LS-C296896 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (clone 2D8) - LS-C198387 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2D8

Anti-TXK / RLK Antibody (N-Terminus) - LS-C99395 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TXK / RLK Antibody (C-Terminus) IHC-plus™ - LS-B10269 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

RLK/TXK Antibody (674801) - MAB6520 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 674801

RLK/TXK Antibody - NBP1-92549 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RLK/TXK Antibody - NBP1-37000 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

RLK/TXK Antibody (2D8) - H00007294-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2D8

RLK/TXK Antibody (2G10) - H00007294-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G10

RLK/TXK Antibody (2E4.) - H00007294-M04 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2E4.

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