| Gene Symbol |
TXK
|
| Entrez Gene |
7294
|
| Alt Symbol |
BTKL, PSCTK5, PTK4, RLK, TKL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TXK tyrosine kinase
|
| Other Description |
PTK4 protein tyrosine kinase 4|protein-tyrosine kinase 4|resting lymphocyte kinase|tyrosine kinase|tyrosine-protein kinase TXK
|
| Swissprots |
Q14220 P42681
|
| Accessions |
AAA19597 AAA19598 AAA19599 AAA19600 AAB60412 EAW93051 EAW93052 EAW93053 P42681 AK300141 BAG61927 AK307055 BC017829 BC166632 AAI66632 DB103575 L27071 AAA74557 XM_011513746 XP_011512048 XM_011513747 XP_011512049 XM_011513748 XP_011512050 XR_925166 NM_003328 NP_003319
|
| Function |
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17177976}. Nucleus {ECO:0000269|PubMed:17177976}. Cell membrane {ECO:0000269|PubMed:17177976}; Peripheral membrane protein {ECO:0000269|PubMed:17177976}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
|
| Tissue Specificity |
Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:7951233}.
|
| Top Pathways |
Leukocyte transendothelial migration
|
