TXK

Gene Symbol	TXK
Entrez Gene	7294
Alt Symbol	BTKL, PSCTK5, PTK4, RLK, TKL
Species	Human
Gene Type	protein-coding
Description	TXK tyrosine kinase
Other Description	PTK4 protein tyrosine kinase 4\|protein-tyrosine kinase 4\|resting lymphocyte kinase\|tyrosine kinase\|tyrosine-protein kinase TXK
Swissprots	Q14220 P42681
Accessions	AAA19597 AAA19598 AAA19599 AAA19600 AAB60412 EAW93051 EAW93052 EAW93053 P42681 AK300141 BAG61927 AK307055 BC017829 BC166632 AAI66632 DB103575 L27071 AAA74557 XM_011513746 XP_011512048 XM_011513747 XP_011512049 XM_011513748 XP_011512050 XR_925166 NM_003328 NP_003319
Function	Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:17177976}. Nucleus {ECO:0000269\|PubMed:17177976}. Cell membrane {ECO:0000269\|PubMed:17177976}; Peripheral membrane protein {ECO:0000269\|PubMed:17177976}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
Tissue Specificity	Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential. {ECO:0000269\|PubMed:10523612, ECO:0000269\|PubMed:7951233}.
Top Pathways	Leukocyte transendothelial migration

Phosphotyrosine TXK / Tyrosine-protein Kinase TXK ELISA Kit - RAB1005 from Sigma-Aldrich

Category	ELISA Kit
Prices	$637.00
Sizes	1 kt

Human Protein Tyrosine Kinase ELISA Kit - abx053279 from Abbexa

Category	ELISA Kit

Protein tyrosine kinase, Human, ELISA Kit - E01P0736 from ARP American Research Products

Category	ELISA Kit
Prices	$535.00, $735.00
Sizes	48 t, 96 t

TXK tyrosine kinase, ELISA Kit - MBS9339936 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity	0.1ng/ml.
Range	0.25 ng/ml - 8 ng/ml.

Human Tyrosine Kinase, Non Receptor 2 (TNK2) ELISA Kit - EKU08008 from Biomatik

Category	ELISA Kit
Prices	$735.00, $3,234.00, $5,880.00
Sizes	96 t, 5x96t, 10x96t
Sensitivity	0.058 ng/mL
Range	0.156-10 ng/mL

Human Protein Tyrosine Kinase ELISA Kit - abx253070 from Abbexa

Category	ELISA Kit
Sensitivity	9.375 pg/ml
Range	15.625 pg/ml - 1000 pg/ml

Human Phosphotyrosine TXK ELISA - PEL-TXK-Y-1 from RayBiotech

Category	ELISA Kit
Prices	$390.00, $702.00, $1,560.00
Sizes	1 plate kit, 2 plate kit, 5 plate kit

JURKAT cells were treated with Pervanadate at 37°C for 10 min. Solubilize cells at 4 x 10^7 cells/ml in lysis buffer. Serial dilutions of lysates were analyzed in this ELISA. Please see step 3 of Part VI Reagent Preparation for detail.

Human TXK ELISA Kit - E101653 from Biobool

Category	ELISA Kit

anti-TXK antibody - ARG64893 from Arigo Biolaboratories

Category	ELISA Kit

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9356218 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9343965 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9358217 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9353520 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9356300 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9362658 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9354476 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9352842 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9364614 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9351054 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9354374 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9361055 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9357835 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9367876 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9369761 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-Protein Kinase TXK (TXK), ELISA Kit - MBS9361518 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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