TXK

Gene Symbol	TXK
Entrez Gene	7294
Alt Symbol	BTKL, PSCTK5, PTK4, RLK, TKL
Species	Human
Gene Type	protein-coding
Description	TXK tyrosine kinase
Other Description	PTK4 protein tyrosine kinase 4|protein-tyrosine kinase 4|resting lymphocyte kinase|tyrosine kinase|tyrosine-protein kinase TXK
Swissprots	Q14220 P42681
Accessions	AAA19597 AAA19598 AAA19599 AAA19600 AAB60412 EAW93051 EAW93052 EAW93053 P42681 AK300141 BAG61927 AK307055 BC017829 BC166632 AAI66632 DB103575 L27071 AAA74557 XM_011513746 XP_011512048 XM_011513747 XP_011512049 XM_011513748 XP_011512050 XR_925166 NM_003328 NP_003319
Function	Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17177976}. Nucleus {ECO:0000269|PubMed:17177976}. Cell membrane {ECO:0000269|PubMed:17177976}; Peripheral membrane protein {ECO:0000269|PubMed:17177976}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
Tissue Specificity	Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:7951233}.
Top Pathways	Leukocyte transendothelial migration

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active TXK protein fragment - ab60900 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Insect cells

Human TXK protein fragment - ab159766 from Abcam Category Protein Source Wheat germ Species Human

TXK / RLK Antibody Blocking Peptide - LS-E25256 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TXK / RLK Antibody Blocking Peptide - LS-E9224 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RLK/TXK Protein - H00007294-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RLK/TXK Recombinant Protein - P3927 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

RLK/TXK Peptide - P2767 from Novus Biologicals Category Peptide Species Human

TXK-Antibody-N-term-Blocking-Peptide - BP7723a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TXK blocking peptide - GTX47607-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

TXK Immunizing peptide - orb55118 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TXK Peptide - AC21-0084-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TXK / PTK4 - H00007294-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TXK / PTK4 - H00007294-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TXK / PTK4 - P3927 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

TXK Peptide - 42-021P from ProSci Category Peptide Species Human

Recombinant Human TXK Tyrosine Kinase, GST-tagged, Active - TXK-453H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human TXK (Active), GST-tagged - TXK-1504H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant TXK Tyrosine Kinase (TXK) - RPG989Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Txk Protein, active, 250 µg - 14-761M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-761) and in bulk (cat# 14-761-K) Source Expressed by baculovirus in Sf21 insect cells.

Recombinant Human Tyrosine-protein kinase TXK(TXK) - CSB-YP025362HU CSB-EP025362HU CSB-BP025362HU CSB-MP025362HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TXK, Peptide - MBS426228 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Pig, Bovine

Tyrosine Kinase Peptide 1, Peptide - MBS658993 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg

Tyrosine Kinase Peptide 3, Peptide - MBS658693 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg

Txk Protein, active, 10 µg - 14-761 from EMD Millipore Category Protein Prices $318.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source Expressed by baculovirus in Sf21 insect cells.

TXK Peptide, Human - M34GP16887H from Creative Peptides Category Peptide Source Synthetic. Species Human

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