Gene Symbol |
INSL3
|
Entrez Gene |
3640
|
Alt Symbol |
RLF, RLNL, ley-I-L
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
insulin-like 3 (Leydig cell)
|
Other Description |
insulin-like 3|leydig insulin -like hormone|leydig insulin-like peptide|prepro-INSL3|relaxin-like factor b
|
Swissprots |
Q3KPI5 G3XAG0 Q3KPI6 Q9UPH6 Q9UEA2 B4DZ72 P51460 Q6YNB5
|
Accessions |
AAD22740 CAA52017 CBH19326 EAW84633 EAW84634 EAW84635 EAW84636 P51460 AK302780 BAG63984 AY082014 AAL92559 BC032810 AAH32810 BC040435 BC053345 AAH53345 BC061886 BC071706 AAH71706 BC106721 AAI06722 BC106722 AAI06723 BC107045 BX334591 S72482 AAB31371 NM_001265587 NP_001252516 NM_005543 NP_005534
|
Function |
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
|
Subcellular Location |
Secreted.
|
Tissue Specificity |
Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast. {ECO:0000269|PubMed:7852540}.
|