Gene Symbol | INSL3 |
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Entrez Gene | 3640 |
Alt Symbol | RLF, RLNL, ley-I-L |
Species | Human |
Gene Type | protein-coding |
Description | insulin-like 3 (Leydig cell) |
Other Description | insulin-like 3|leydig insulin -like hormone|leydig insulin-like peptide|prepro-INSL3|relaxin-like factor b |
Swissprots | Q3KPI5 G3XAG0 Q3KPI6 Q9UPH6 Q9UEA2 B4DZ72 P51460 Q6YNB5 |
Accessions | AAD22740 CAA52017 CBH19326 EAW84633 EAW84634 EAW84635 EAW84636 P51460 AK302780 BAG63984 AY082014 AAL92559 BC032810 AAH32810 BC040435 BC053345 AAH53345 BC061886 BC071706 AAH71706 BC106721 AAI06722 BC106722 AAI06723 BC107045 BX334591 S72482 AAB31371 NM_001265587 NP_001252516 NM_005543 NP_005534 |
Function | Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast. {ECO:0000269|PubMed:7852540}. |
INSL3 CRISPR/Cas9 KO Plasmid (h) - sc-409637 from Santa Cruz Biotechnology
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INSL3 HDR Plasmid (h) - sc-409637-HDR from Santa Cruz Biotechnology
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INSL3 Double Nickase Plasmid (h) - sc-409637-NIC from Santa Cruz Biotechnology
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INSL3 Double Nickase Plasmid (h2) - sc-409637-NIC-2 from Santa Cruz Biotechnology
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INSL3 CRISPR Activation Plasmid (h) - sc-409637-ACT from Santa Cruz Biotechnology
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INSL3 CRISPR Activation Plasmid (h2) - sc-409637-ACT-2 from Santa Cruz Biotechnology
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INSL3 Lentiviral Activation Particles (h) - sc-409637-LAC from Santa Cruz Biotechnology
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INSL3 Lentiviral Activation Particles (h2) - sc-409637-LAC-2 from Santa Cruz Biotechnology
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INSL3 siRNA (h) - sc-60854 from Santa Cruz Biotechnology
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INSL3 shRNA Plasmid (h) - sc-60854-SH from Santa Cruz Biotechnology
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INSL3 shRNA (h) Lentiviral Particles - sc-60854-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10702 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10702 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02779 from Sigma-Aldrich
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INSL3 siRNA (Human) - CRH2440 from Cohesion Biosciences
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INSL3 - MBS8201317 from MyBioSource
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shRNA set against Human INSL3 (NM_005543.3) - SHH319845 from Creative biogene
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Human INSL3 siRNA - orb262942 from Biorbyt
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INSL3 shRNA Plasmid (Human) - CHH2440 from Cohesion Biosciences
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INSL3 miRNA 3'UTR clone - MiUTR4H-TG04537 from Creative biogene
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