| Gene Symbol |
MYCBP2
|
| Entrez Gene |
23077
|
| Alt Symbol |
PAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MYC binding protein 2, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase MYCBP2|myc-binding protein 2|pam/highwire/rpm-1 protein|probable E3 ubiquitin-protein ligase MYCBP2|protein associated with Myc
|
| Swissprots |
Q9UQ11 Q6PIB6 Q9Y6E4 Q5VZN6 Q5JSX8 O75592 A6NJC6
|
| Accessions |
EAW80564 EAW80565 EAW80566 EAW80567 O75592 AA236471 AB020723 BAA74939 AF075587 AAC39928 AF083244 AAD39842 AK000968 BAA91448 AK023888 AK025250 AK025299 AK092651 AL110277 CAB53712 BC037971 AAH37971 BE886946 BI859936 BX473679 BX647202 CN395460 CN395461 XM_005266299 XP_005266356 XM_006719779 XP_006719842 XM_006719780 XP_006719843 XM_006719781 XP_006719844 XM_006719782 XP_006719845 XM_006719783 XP_006719846 XM_006719784 XP_006719847 XM_006719785 XP_006719848 XM_006719786 XP_006719849 XM_006719787 XP_006719850 XM_006719788 XP_006719851 XM_006719789 XP_006719852 XM_011535003 XP_011533305 XM_011535004 XP_011533306 XM_011535005 XP_011533307 NM_015057 NP_055872
|
| Function |
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis. {ECO:0000269|PubMed:18308511}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9689053}.
|
| Tissue Specificity |
Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone. {ECO:0000269|PubMed:9689053}.
|