MYCBP2

Gene Symbol MYCBP2
Entrez Gene 23077
Alt Symbol PAM
Species Human
Gene Type protein-coding
Description MYC binding protein 2, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase MYCBP2|myc-binding protein 2|pam/highwire/rpm-1 protein|probable E3 ubiquitin-protein ligase MYCBP2|protein associated with Myc
Swissprots Q9UQ11 Q6PIB6 Q9Y6E4 Q5VZN6 Q5JSX8 O75592 A6NJC6
Accessions EAW80564 EAW80565 EAW80566 EAW80567 O75592 AA236471 AB020723 BAA74939 AF075587 AAC39928 AF083244 AAD39842 AK000968 BAA91448 AK023888 AK025250 AK025299 AK092651 AL110277 CAB53712 BC037971 AAH37971 BE886946 BI859936 BX473679 BX647202 CN395460 CN395461 XM_005266299 XP_005266356 XM_006719779 XP_006719842 XM_006719780 XP_006719843 XM_006719781 XP_006719844 XM_006719782 XP_006719845 XM_006719783 XP_006719846 XM_006719784 XP_006719847 XM_006719785 XP_006719848 XM_006719786 XP_006719849 XM_006719787 XP_006719850 XM_006719788 XP_006719851 XM_006719789 XP_006719852 XM_011535003 XP_011533305 XM_011535004 XP_011533306 XM_011535005 XP_011533307 NM_015057 NP_055872
Function E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis. {ECO:0000269|PubMed:18308511}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9689053}.
Tissue Specificity Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone. {ECO:0000269|PubMed:9689053}.

Pam CRISPR/Cas9 KO Plasmid (h) - sc-407652 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pam HDR Plasmid (h) - sc-407652-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pam Double Nickase Plasmid (h) - sc-407652-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pam Double Nickase Plasmid (h2) - sc-407652-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pam CRISPR Activation Plasmid (h) - sc-407652-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pam CRISPR Activation Plasmid (h2) - sc-407652-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pam Lentiviral Activation Particles (h) - sc-407652-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pam Lentiviral Activation Particles (h2) - sc-407652-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pam siRNA (h) - sc-76038 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pam shRNA Plasmid (h) - sc-76038-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pam shRNA (h) Lentiviral Particles - sc-76038-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Peptidylglycine alpha-Amidating Monooxygenase/PAM RNAi - H00005066-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Peptidylglycine alpha-Amidating Monooxygenase/PAM RNAi - H00005066-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MYCBP2 RNAi - H00023077-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU095641 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU098131 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU092191 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14801 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14801 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06089 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06089

MYCBP2 siRNA (Human) - CRH7981 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MYCBP2 (NM_015057.4) - SHH347548 from Creative biogene

Category siRNA
Species Reactivities Human

Human MYCBP2 siRNA - orb268483 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MYCBP2 shRNA Plasmid (Human) - CHH7981 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MYCBP2 miRNA 3'UTR clone - MiUTR3H-11205 from Creative biogene

Species Reactivities Human
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