MYCBP2

Gene Symbol MYCBP2
Entrez Gene 23077
Alt Symbol PAM
Species Human
Gene Type protein-coding
Description MYC binding protein 2, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase MYCBP2|myc-binding protein 2|pam/highwire/rpm-1 protein|probable E3 ubiquitin-protein ligase MYCBP2|protein associated with Myc
Swissprots Q9UQ11 Q6PIB6 Q9Y6E4 Q5VZN6 Q5JSX8 O75592 A6NJC6
Accessions EAW80564 EAW80565 EAW80566 EAW80567 O75592 AA236471 AB020723 BAA74939 AF075587 AAC39928 AF083244 AAD39842 AK000968 BAA91448 AK023888 AK025250 AK025299 AK092651 AL110277 CAB53712 BC037971 AAH37971 BE886946 BI859936 BX473679 BX647202 CN395460 CN395461 XM_005266299 XP_005266356 XM_006719779 XP_006719842 XM_006719780 XP_006719843 XM_006719781 XP_006719844 XM_006719782 XP_006719845 XM_006719783 XP_006719846 XM_006719784 XP_006719847 XM_006719785 XP_006719848 XM_006719786 XP_006719849 XM_006719787 XP_006719850 XM_006719788 XP_006719851 XM_006719789 XP_006719852 XM_011535003 XP_011533305 XM_011535004 XP_011533306 XM_011535005 XP_011533307 NM_015057 NP_055872
Function E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis. {ECO:0000269|PubMed:18308511}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9689053}.
Tissue Specificity Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone. {ECO:0000269|PubMed:9689053}.

Pam (S-20) - sc-84546 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-MYCBP2 antibody - ab86078 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MYCBP2 antibody (ab86078) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µg

MYCBP2 Antibody - NB100-97841 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MYCBP2 Antibody [NB100-97841] - Whole cell lysate (5, 15, 50 ug loaded) from HeLa cells probed with anti-MYCBP2 antibody at 0.04 ug/ml.

MYCBP2 Antibody - NBP1-84647 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunohistochemistry: MYCBP2 Antibody [NBP1-84647] - Staining of human testis shows distinct cytoplasmic positivity in cells of seminiferus ducts.

MYCBP2 Polyclonal Antibody - bs-9375R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded rat brain tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-MYCBP2 Polyclonal Antibody, Unconjugated (bs-9375R) at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining

Anti-MYCBP2 antibody produced in rabbit - HPA039945 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MYCBP2: <B>Cat. No. HPA039945</B>: Immunohistochemical staining of human testis shows distinct cytoplasmic positivity in cells of seminiferus ducts.

PAM Antibody - C-terminal region (ARP43549_P050) - ARP43549_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PAM antibody - GTX115035 from GeneTex

Host Rabbit
Clonality Polyclonal

PAM antibody [N3C3] - GTX106062 from GeneTex

Host Rabbit
Clonality Polyclonal

PAM Antibody - A301-833A from Bethyl Labs

Prices $99.00, $229.00, $339.00
Sizes 20 µl (2 blots), 100 µl (10 blots), 100 µl (0.2 mg/ml)
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-9375R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-9375R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-9375R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-9375R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, Cy3 Conjugated - bs-9375R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, Cy5 Conjugated - bs-9375R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, Cy5.5 Conjugated - bs-9375R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, Cy7 Conjugated - bs-9375R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, FITC Conjugated - bs-9375R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, Biotin Conjugated - bs-9375R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, HRP Conjugated - bs-9375R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PAM, Polyclonal Antibody - MBS5303458 from MyBioSource

Prices $455.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

MYCBP2 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated - bs-9375R-A594 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PAM antibody - orb337119 from Biorbyt

Prices $238.00, $281.00, $323.00
Sizes 20 μl (Trial Size), 50 μl, 100 μl
Host Rabbit
Clonality Polyclonal
Clone $155
Western blot analysis of HuvEc whole cell lysates using PAM antibody
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