MYCBP2

Gene Symbol	MYCBP2
Entrez Gene	23077
Alt Symbol	PAM
Species	Human
Gene Type	protein-coding
Description	MYC binding protein 2, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MYCBP2|myc-binding protein 2|pam/highwire/rpm-1 protein|probable E3 ubiquitin-protein ligase MYCBP2|protein associated with Myc
Swissprots	Q9UQ11 Q6PIB6 Q9Y6E4 Q5VZN6 Q5JSX8 O75592 A6NJC6
Accessions	EAW80564 EAW80565 EAW80566 EAW80567 O75592 AA236471 AB020723 BAA74939 AF075587 AAC39928 AF083244 AAD39842 AK000968 BAA91448 AK023888 AK025250 AK025299 AK092651 AL110277 CAB53712 BC037971 AAH37971 BE886946 BI859936 BX473679 BX647202 CN395460 CN395461 XM_005266299 XP_005266356 XM_006719779 XP_006719842 XM_006719780 XP_006719843 XM_006719781 XP_006719844 XM_006719782 XP_006719845 XM_006719783 XP_006719846 XM_006719784 XP_006719847 XM_006719785 XP_006719848 XM_006719786 XP_006719849 XM_006719787 XP_006719850 XM_006719788 XP_006719851 XM_006719789 XP_006719852 XM_011535003 XP_011533305 XM_011535004 XP_011533306 XM_011535005 XP_011533307 NM_015057 NP_055872
Function	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis. {ECO:0000269|PubMed:18308511}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9689053}.
Tissue Specificity	Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone. {ECO:0000269|PubMed:9689053}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Human Peptidylglycine alpha-Amidating Monooxygenase/PAM Protein - H00005066-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Peptidylglycine alpha-Amidating Monooxygenase/PAM Protein - H00005066-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human PAM (Fc Tag) protein - orb232316 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 10 μg, 50 μg Species Human

Human PAM (His Tag) protein - orb232317 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 10 μg, 50 μg Species Human

PAM Blocking Peptide - 33R-7169 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human PAM / Peptidylglycine alpha‑Amidating Monooxygenase Protein (Fc Tag) - 13624-H02H-10 from Sino Biological Category Protein Source Human Cells Species Human

Human PAM / Peptidylglycine alpha‑Amidating Monooxygenase Protein (His Tag) - 13624-H08H-10 from Sino Biological Category Protein Source Human Cells Species Human

Recombinant Human Probable E3 ubiquitin-protein ligase MYCBP2(MYCBP2) ,partial - CSB-YP015272HU CSB-EP015272HU CSB-BP015272HU CSB-MP015272HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Probable E3 ubiquitin-protein ligase MYCBP2 (MYCBP2), partial, Recombinant Protein - MBS1160876 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Peptidylglycine alpha-Amidating Monooxygenase/PAM Protein - NBP2-34075PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

MYCBP2 Peptide, Human - M34GP09973H from Creative Peptides Category Peptide Source Synthetic. Species Human

PAM Peptide, Human - M34GP11271H from Creative Peptides Category Peptide Source Synthetic. Species Human

PAM fusion protein - Ag25732 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MYCBP2 fusion protein - Ag27228 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

MYCBP2 fusion protein - Ag27162 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

PAM fusion protein - Ag25719 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

PAM Immunizing peptide - orb50409 from Biorbyt Category Peptide

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