| Gene Symbol |
CTGF
|
| Entrez Gene |
1490
|
| Alt Symbol |
CCN2, HCS24, IGFBP8, NOV2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
connective tissue growth factor
|
| Other Description |
CCN family member 2|IBP-8|IGF-binding protein 8|IGFBP-8|hypertrophic chondrocyte-specific protein 24|insulin-like growth factor-binding protein 8
|
| Swissprots |
Q6LCY0 Q96A79 P29279 Q96QX2 Q9UDL6 E1P578
|
| Accessions |
AAK60505 AAK60506 AAK60507 AAZ29611 ADL14512 CAA63267 CAS92743 CBX51740 EAW48038 EAW48039 P29279 AF127918 AK092280 BAG52518 AK125220 BAG54167 AK290884 BAF83573 AK315207 BAG37644 AY395801 AAQ95223 AY550024 AAS55639 BC087839 AAH87839 BT019794 AAV38597 BT019795 AAV38598 CR541734 CAG46534 CR541759 CAG46559 DA552292 M92934 AAA91279 U14750 AAA75378 X78947 CAA55544 NM_001901 NP_001892
|
| Function |
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. {ECO:0000269|PubMed:10614647, ECO:0000269|PubMed:12553878}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted {ECO:0000250}.
|
| Tissue Specificity |
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. {ECO:0000269|PubMed:1756408}.
|
| Top Pathways |
Hippo signaling pathway
|