| Gene Symbol |
AGO1
|
| Entrez Gene |
26523
|
| Alt Symbol |
EIF2C, EIF2C1, GERP95, Q99
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
argonaute RISC catalytic component 1
|
| Other Description |
Golgi Endoplasmic Reticulum protein 95 kDa|argonaute 1|argonaute1|eIF-2C 1|eIF2C 1|eukaryotic translation initiation factor 2C, 1|hAgo1|protein argonaute-1|putative RNA-binding protein Q99
|
| Swissprots |
Q9UL18 Q5TA57 Q6P4S0
|
| Accessions |
EAX07396 Q9UL18 AF093097 AAF00068 AK000326 AK001622 BAG50952 AK002003 AK025726 AK027611 AK125879 AK314148 BAG36835 BC063275 AAH63275 CR936823 U92986 XM_011541236 XP_011539538 XM_011541237 XP_011539539 XM_011541238 XP_011539540 XM_011541239 XP_011539541 NM_012199 NP_036331
|
| Function |
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:18771919}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:20616046}.
|