Gene Symbol | AGO1 |
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Entrez Gene | 26523 |
Alt Symbol | EIF2C, EIF2C1, GERP95, Q99 |
Species | Human |
Gene Type | protein-coding |
Description | argonaute RISC catalytic component 1 |
Other Description | Golgi Endoplasmic Reticulum protein 95 kDa|argonaute 1|argonaute1|eIF-2C 1|eIF2C 1|eukaryotic translation initiation factor 2C, 1|hAgo1|protein argonaute-1|putative RNA-binding protein Q99 |
Swissprots | Q9UL18 Q5TA57 Q6P4S0 |
Accessions | EAX07396 Q9UL18 AF093097 AAF00068 AK000326 AK001622 BAG50952 AK002003 AK025726 AK027611 AK125879 AK314148 BAG36835 BC063275 AAH63275 CR936823 U92986 XM_011541236 XP_011539538 XM_011541237 XP_011539539 XM_011541238 XP_011539540 XM_011541239 XP_011539541 NM_012199 NP_036331 |
Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:18771919}. |
Subcellular Location | Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:20616046}. |
Ago1 peptide - ab203560 from Abcam
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D. melanogaster Ago1 peptide - ab23538 from Abcam
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Human Ago1 full length protein - ab162000 from Abcam
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Human Ago1 protein fragment - ab162001 from Abcam
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S. pombe Ago1 peptide - ab19149 from Abcam
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AGO1 / EIF2C Antibody Blocking Peptide - LS-E8286 from LifeSpan Bioscience
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AGO1 / EIF2C Antibody Blocking Peptide - LS-E26045 from LifeSpan Bioscience
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AGO1 / EIF2C Antibody Blocking Peptide - LS-E19785 from LifeSpan Bioscience
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Recombinant Human AGO1/EIF2C1 Protein - H00026523-Q01 from Novus Biologicals
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Recombinant Human AGO1/EIF2C1 Protein - H00026523-P01 from Novus Biologicals
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AGO1-Antibody-N-term-Blocking-Peptide - BP6558a from Abgent, a WuXi AppTec company
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AGO1 blocking peptide - GTX89393-PEP from GeneTex
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Human AGO1 His tag protein - orb83538 from Biorbyt
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EIF2C1 Blocking Peptide - 33R-5890 from Fitzgerald
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Ago1 Peptide - AC21-0873-P from Abcore
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EIF2C1 / AGO1 - H00026523-P01 from Acris Antibodies
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EIF2C1 / AGO1 - H00026523-Q01-10 from Acris Antibodies
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EIF2C1 / AGO1 - H00026523-Q01-25 from Acris Antibodies
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EIF2C1 Peptide - 45-525P from ProSci
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EIF2C1 fusion protein - ag10608 from Proteintech Group
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Recombinant Human EIF2C1, His tagged - EIF2C1-2196H from Creative Biomart
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AGO1 - PN201235 from Elabscience
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Human AGO1 / Argonaute 1 / EIF2C1 Protein (His Tag) - 11225-H07B-20 from Sino Biological
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Recombinant Human Protein argonaute-1(EIF2C1) ,partial - CSB-YP892141HU CSB-EP892141HU CSB-BP892141HU CSB-MP892141HU from Cusabio
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Protein argonaute-1 (EIF2C1), partial, Recombinant Protein - MBS1429559 from MyBioSource
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