| Gene Symbol | S1PR3 |
|---|---|
| Entrez Gene | 1903 |
| Alt Symbol | EDG-3, EDG3, LPB3, S1P3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sphingosine-1-phosphate receptor 3 |
| Other Description | G protein-coupled receptor, endothelial differentiation gene-3|S1P receptor 3|S1P receptor EDG3|S1P receptor Edg-3|endothelial differentiation G-protein coupled receptor 3|endothelial differentiation, sphingolipid G-protein-coupled receptor, 3|sphingosine 1-phosphate receptor 3|sphingosine 1-phosphate receptor Edg-3 |
| Swissprots | Q99500 Q5SQD8 Q7Z5I2 |
| Accessions | AAP84353 CAA58744 EAW62758 Q99500 AF022139 AAC51906 AK312798 BAG35658 AL832194 BC060827 AAH60827 BC069579 AAH69579 BM990167 DA722994 DR763542 NM_005226 NP_005217 |
| Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269|PubMed:10617617}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. |
| Top Pathways | Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction |