| Gene Symbol |
S1PR3
|
| Entrez Gene |
1903
|
| Alt Symbol |
EDG-3, EDG3, LPB3, S1P3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingosine-1-phosphate receptor 3
|
| Other Description |
G protein-coupled receptor, endothelial differentiation gene-3|S1P receptor 3|S1P receptor EDG3|S1P receptor Edg-3|endothelial differentiation G-protein coupled receptor 3|endothelial differentiation, sphingolipid G-protein-coupled receptor, 3|sphingosine 1-phosphate receptor 3|sphingosine 1-phosphate receptor Edg-3
|
| Swissprots |
Q99500 Q5SQD8 Q7Z5I2
|
| Accessions |
AAP84353 CAA58744 EAW62758 Q99500 AF022139 AAC51906 AK312798 BAG35658 AL832194 BC060827 AAH60827 BC069579 AAH69579 BM990167 DA722994 DR763542 NM_005226 NP_005217
|
| Function |
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269|PubMed:10617617}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
|
| Top Pathways |
Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction
|