Gene Symbol | S1PR3 |
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Entrez Gene | 1903 |
Alt Symbol | EDG-3, EDG3, LPB3, S1P3 |
Species | Human |
Gene Type | protein-coding |
Description | sphingosine-1-phosphate receptor 3 |
Other Description | G protein-coupled receptor, endothelial differentiation gene-3|S1P receptor 3|S1P receptor EDG3|S1P receptor Edg-3|endothelial differentiation G-protein coupled receptor 3|endothelial differentiation, sphingolipid G-protein-coupled receptor, 3|sphingosine 1-phosphate receptor 3|sphingosine 1-phosphate receptor Edg-3 |
Swissprots | Q99500 Q5SQD8 Q7Z5I2 |
Accessions | AAP84353 CAA58744 EAW62758 Q99500 AF022139 AAC51906 AK312798 BAG35658 AL832194 BC060827 AAH60827 BC069579 AAH69579 BM990167 DA722994 DR763542 NM_005226 NP_005217 |
Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269|PubMed:10617617}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. |
Top Pathways | Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction |
Human EDG3 full length protein - ab152356 from Abcam
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Human EDG3 peptide - ab74476 from Abcam
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Human EDG3 protein fragment - ab114632 from Abcam
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SIPR3 / EDG3 / S1P3 Antibody Blocking Peptide - LS-E8093 from LifeSpan Bioscience
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SIPR3 / EDG3 / S1P3 Antibody Blocking Peptide - LS-E28402 from LifeSpan Bioscience
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SIPR3 / EDG3 / S1P3 Antibody Blocking Peptide - LS-E28102 from LifeSpan Bioscience
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SIPR3 / EDG3 / S1P3 Antibody Blocking Peptide - LS-E28103 from LifeSpan Bioscience
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SIPR3 / EDG3 / S1P3 Antibody Blocking Peptide - LS-E24067 from LifeSpan Bioscience
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Recombinant Human S1P3/EDG-3 Protein - H00001903-P01 from Novus Biologicals
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S1P3/EDG-3 Partial Recombinant Protein - H00001903-Q01 from Novus Biologicals
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Recombinant Human S1P3/EDG-3 Protein - H00001903-P02 from Novus Biologicals
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S1P3/EDG-3 Peptide - P1747 from Novus Biologicals
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EDG3-Antibody-N-term-Blocking-Peptide - BP6139a from Abgent, a WuXi AppTec company
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S1PR3 peptide - orb217225 from Biorbyt
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EDG3 Blocking Peptide - abx062556 from Abbexa
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EDG3 / S1P3 - H00001903-G01 from Acris Antibodies
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EDG3 / S1P3 - H00001903-P01 from Acris Antibodies
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EDG3 / S1P3 - H00001903-Q01-10 from Acris Antibodies
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EDG3 / S1P3 - H00001903-Q01-25 from Acris Antibodies
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S1PR3 fusion protein - ag6397 from Proteintech Group
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Recombinant Human S1PR3 - S1PR3-28463TH from Creative Biomart
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Recombinant Sphingosine 1 Phosphate Receptor 3 (S1PR3) - RPE693Hu01 from Uscn Life Science Inc.
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Recombinant Sphingosine 1 Phosphate Receptor 3 (S1PR3) - RPE693Mu01 from Uscn Life Science Inc.
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Recombinant Sphingosine 1 Phosphate Receptor 3 (S1PR3) - RPE693Mu02 from Uscn Life Science Inc.
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Recombinant Sphingosine 1 Phosphate Receptor 3 (S1PR3) - RPE693Ra01 from Uscn Life Science Inc.
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